ALKBH5 anticorps (Internal Region)

N° du produit ABIN6259460

Détail du produit anti-ALKBH5 anticorps

Antigène: ALKBH5 (AlkB, Alkylation Repair Homolog 5 (ALKBH5))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ALKBH5 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificité: ALKBH5 Antibody detects endogenous levels of total ALKBH5.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human ALKBH5, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Date de péremption: 12 months

Détails sur ALKBH5

Antigène: ALKBH5 (AlkB, Alkylation Repair Homolog 5 (ALKBH5))

Autre désignation: ALKBH5 (ALKBH5 Produits)

Synonymes: anticorps RGD1309496, anticorps ABH5, anticorps OFOXD, anticorps OFOXD1, anticorps AW050020, anticorps AW215868, anticorps Abh5, anticorps E130207K11, anticorps Ofoxd, anticorps alkB homolog 5, RNA demethylase, anticorps alkB homolog 5, RNA demethylase L homeolog, anticorps Alkbh5, anticorps alkbh5.L, anticorps ALKBH5

Sujet:

Description: Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N6-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24778178, PubMed:24616105, PubMed:24489119). Can also demethylate N6-methyladenosine in single-stranded DNA (in vitro) (PubMed:24616105). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24778178, PubMed:24616105, PubMed:24489119). Demethylation of m6A mRNA affects mRNA processing and export (PubMed:23177736). Required for spermatogenesis (By similarity).

Gene: ALKBH5

Poids moléculaire: ?44 kDa

ID gène: 54890

UniProt: Q6P6C2