HUWE1 anticorps (Internal Region)

N° du produit ABIN6259492

Détail du produit anti-HUWE1 anticorps

Antigène: HUWE1 (HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1))

Épitope: Internal Region

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HUWE1 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: HUWE1 Antibody detects endogenous levels of total HUWE1.

Homologie: Rabbit

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human HUWE1, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Date de péremption: 12 months

Détails sur HUWE1

Antigène: HUWE1 (HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1))

Autre désignation: HUWE1 (HUWE1 Produits)

Synonymes: anticorps ARF-BP1, anticorps HECTH9, anticorps HSPC272, anticorps Ib772, anticorps LASU1, anticorps MULE, anticorps URE-B1, anticorps UREB1, anticorps 5430439H10Rik, anticorps AU041296, anticorps Arf-bp1, anticorps C430014N20Rik, anticorps C80292, anticorps Gm1718, anticorps Mule, anticorps Ureb1, anticorps HUWE1, anticorps si:dkey-242a8.2, anticorps Huwe1, anticorps mule, anticorps ib772, anticorps lasu1, anticorps ureb1, anticorps hecth9, anticorps arf-bp1, anticorps hspc272, anticorps HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase, anticorps HECT, UBA and WWE domain containing 1, anticorps E3 ubiquitin-protein ligase HUWE1, anticorps HUWE1, anticorps Huwe1, anticorps huwe1, anticorps LOC100123214, anticorps LOC100380641

Sujet:

Description: E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation. Mediates polyubiquitination of isoform 2 of PA2G4.

Gene: HUWE1

Poids moléculaire: 481 kDa

ID gène: 10075

UniProt: Q7Z6Z7