ARHGEF4 anticorps (Internal Region)

N° du produit ABIN6260035

Détail du produit anti-ARHGEF4 anticorps

Antigène: ARHGEF4 (rho Guanine Nucleotide Exchange Factor (GEF) 4 (ARHGEF4))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ARHGEF4 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: ARHGEF4 Antibody detects endogenous levels of total ARHGEF4.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human ARHGEF4, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur ARHGEF4

Antigène: ARHGEF4 (rho Guanine Nucleotide Exchange Factor (GEF) 4 (ARHGEF4))

Autre désignation: ARHGEF4 (ARHGEF4 Produits)

Synonymes: anticorps ARHGEF4, anticorps ASEF, anticorps ASEF1, anticorps GEF4, anticorps STM6, anticorps 9330140K16Rik, anticorps Asef, anticorps ENSMUSG00000070955, anticorps Rho guanine nucleotide exchange factor 4, anticorps uncharacterized LOC100470646, anticorps rho guanine nucleotide exchange factor 4, anticorps Rho guanine nucleotide exchange factor (GEF) 4, anticorps ARHGEF4, anticorps arhg4, anticorps LOC100470646, anticorps LOC100544917, anticorps Arhgef4

Sujet:

Description: Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.

Gene: ARHGEF4

Poids moléculaire: 79 kDa

ID gène: 50649

UniProt: Q9NR80

Pathways: Neurotrophin Signaling Pathway