Ataxin 3 anticorps (Internal Region)

N° du produit ABIN6260149

Détail du produit anti-Ataxin 3 anticorps

Antigène: Ataxin 3 (ATXN3)

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Ataxin 3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificité: Ataxin 3 Antibody detects endogenous levels of total Ataxin 3.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human Ataxin 3, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur Ataxin 3

Antigène: Ataxin 3 (ATXN3)

Autre désignation: ATXN3 (ATXN3 Produits)

Synonymes: anticorps Mjd, anticorps zgc:56323, anticorps ATXN3, anticorps at3, anticorps jos, anticorps mjd, anticorps atx3, anticorps mjd1, anticorps sca3, anticorps ataxin-3, anticorps MJD1, anticorps MGC83584, anticorps AT3, anticorps ATX3, anticorps JOS, anticorps MJD, anticorps SCA3, anticorps 2210008M02Rik, anticorps AI463012, anticorps AI647473, anticorps Sca3, anticorps Rsca3, anticorps ataxin 3, anticorps ataxin 3 L homeolog, anticorps ataxin-3, anticorps atxn3, anticorps ATXN3, anticorps atxn3.L, anticorps MICPUN_104046, anticorps MICPUCDRAFT_46658, anticorps Atxn3

Sujet:

Description: Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (PubMed:12297501, PubMed:17696782, PubMed:23625928, PubMed:28445460, PubMed:16118278). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (PubMed:17696782). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (PubMed:12297501). Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (PubMed:28445460).

Gene: ATXN3

Poids moléculaire: 43kDa

ID gène: 4287

UniProt: P54252