CCRN4L anticorps

N° du produit ABIN6260565

Détail du produit anti-CCRN4L anticorps

Antigène: CCRN4L (CCR4 Carbon Catabolite Repression 4-Like (CCRN4L))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CCRN4L est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: CCRN4L Antibody detects endogenous levels of total CCRN4L

Réactivité croisée: Humain, Souris, Rat (Rattus)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human CCRN4L

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C.Stable for 12 months from date of receipt

Date de péremption: 12 months

Détails sur CCRN4L

Antigène: CCRN4L (CCR4 Carbon Catabolite Repression 4-Like (CCRN4L))

Autre désignation: CCRN4L (CCRN4L Produits)

Synonymes: anticorps CCR4L, anticorps NOC, anticorps AU043840, anticorps Ccr4, anticorps nocturnin, anticorps Ccrn4lb, anticorps MNOC, anticorps ccr4l, anticorps noc, anticorps MGC85016, anticorps ccrn4l, anticorps CCRN4L, anticorps nocturnin, anticorps nocturnin S homeolog, anticorps nocturnin L homeolog, anticorps putative nocturnin, anticorps NOCT, anticorps Noct, anticorps noct, anticorps noct.S, anticorps noct.L, anticorps LOC5570471, anticorps CpipJ_CPIJ011434, anticorps Smp_105040

Sujet:

Description: Circadian deadenylase which plays an important role in post-transcriptional regulation of metabolic genes under circadian control. Degrades poly(A) tails of specific target mRNAs leading to their degradation and suppression of translation. Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis. Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance. Promotes adipogenesis by activating PPARG transcriptional activity in a deadenylase-independent manner by facilitating its nuclear translocation. Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone. Critical for proper development of early embryos (By similarity).

Gene: NOCT

Poids moléculaire: 48 kDa

ID gène: 25819

UniProt: Q9UK39

Pathways: Ribonucleoprotein Complex Subunit Organization