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CD3 epsilon anticorps (C-Term)

Name: CD3 epsilon anticorps (C-Term)
SKU: ABIN6260619
Price: 728.46 EUR
Availability: InStock

CD3E Reactivité: Humain, Souris, Rat WB, IHC, IF, ELISA, ICC Hôte: Lapin Polyclonal unconjugated

Western blot analysis of extracts of Jurkat, using CD3E antibody. (CD3 epsilon anticorps (C-Term))

ABIN6276857 at 1/100 staining Human liver cancer tissue by IHC-P. (CD3 epsilon anticorps (C-Term))

IHC

ABIN6276857 staining HepG2? (CD3 epsilon anticorps (C-Term))

IF/ICC

Western blot analysis of extracts from rat muscle, using CD3E Antibody. (CD3 epsilon anticorps (C-Term))

4 images

(1 reference)

N° du produit ABIN6260619

Fiche de données

Antigène Voir toutes CD3 epsilon (CD3E) Anticorps

CD3 epsilon (CD3E)
Épitope
25

20

16

16

16

14

13

9

8

6

4

4

3

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1
C-Term
Reactivité
218

180

44

41

18

8

8

8

7

4

4

4

4

3

3

3

3

3

3

1

1

1

1

1
Humain, Souris, Rat
Hôte
142

120

45

24

22

10

1
Lapin
Anticorps secondaires appropriés
Clonalité
238

120

6
Polyclonal
Conjugué
132

32

29

21

16

8

7

7

7

6

6

4

4

4

4

4

4

4

4

4

4

4

4

4

3

3

3

3

3

3

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1
Cet anticorp CD3 epsilon est non-conjugé
Application
252

162

87

85

78

69

32

27

25

22

14

14

13

13

8

6

5

4

4

3

3

3

3

2

1

1

1

1

1

1

1

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA, Immunocytochemistry (ICC)

Specificité

CD3 epsilon Antibody detects endogenous levels of total CD3 epsilon.

Homologie

Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Purification

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène

A synthesized peptide derived from human CD3E, corresponding to a region within C-terminal amino acids.

Isotype

IgG

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CD3E Reactivité: Humain WB, IHC, IP Hôte: Lapin Polyclonal unconjugated

anti-CD3 epsilon (CD3E) (AA 25-126) antibody
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anti-CD3 epsilon (CD3E) (AA 28-185) antibody
CD3E Reactivité: Humain WB, IHC, IP, ICC Hôte: Lapin Polyclonal unconjugated

Indications d'application

WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions

For Research Use only
Format

Liquid

Concentration

1 mg/mL

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur

Sodium azide

Précaution d'utilisation

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock

-20 °C

Stockage commentaire

Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption

12 months
Guo, Xue, Li, Yang, Wang, Ma, Zhang, Wang, Zhao, Chang, Chen: "Protective effects of triptolide on TLR4 mediated autoimmune and inflammatory response induced myocardial fibrosis in diabetic cardiomyopathy." dans: Journal of ethnopharmacology, Vol. 193, pp. 333-344, (2017) (PubMed).
Antigène

CD3 epsilon (CD3E)

Autre désignation

CD3E (CD3E Produits)

Synonymes

anticorps cd3e, anticorps CD3E, anticorps t3e, anticorps tcre, anticorps AI504783, anticorps CD3, anticorps CD3epsilon, anticorps T3e, anticorps T3E, anticorps TCRE, anticorps CD3e molecule, anticorps CD3 antigen, epsilon polypeptide, anticorps cd3e, anticorps CD3E, anticorps Cd3e

Sujet

Description: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell developement. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region (PubMed:10384095, PubMed:26507128).
Gene: CD3E

Poids moléculaire

23kDa

ID gène

916

UniProt

P07766

Pathways

TCR Signaling, CXCR4-mediated Signaling Events, Ubiquitin Proteasome Pathway