CHAC1 anticorps (Internal Region)

N° du produit ABIN6260788

Détail du produit anti-CHAC1 anticorps

Antigène: CHAC1 (ChaC, Cation Transport Regulator Homolog 1 (CHAC1))

Épitope: Internal Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CHAC1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: CHAC1 Antibody detects endogenous levels of total CHAC1.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human CHAC1, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur CHAC1

Antigène: CHAC1 (ChaC, Cation Transport Regulator Homolog 1 (CHAC1))

Autre désignation: CHAC1 (CHAC1 Produits)

Synonymes: anticorps 1810008K03Rik, anticorps RGD1307153, anticorps ChaC glutathione specific gamma-glutamylcyclotransferase 1, anticorps ChaC, cation transport regulator 1, anticorps ChaC glutathione-specific gamma-glutamylcyclotransferase 1, anticorps CHAC1, anticorps Chac1

Sujet:

Description: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides (PubMed:27913623). Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (PubMed:19109178). Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos (PubMed:22445366).

Gene: CHAC1

Poids moléculaire: 29kDa

ID gène: 79094

UniProt: Q9BUX1