C-Type Lectin Domain Family 6, Member A (CLEC6A) (Internal Region) anticorps

N° du produit ABIN6260891

Détail du produit

Antigène: C-Type Lectin Domain Family 6, Member A (CLEC6A)

Épitope: Internal Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: CLEC6A Antibody detects endogenous levels of total CLEC6A.

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human CLEC6A, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détail du antigène

Antigène: C-Type Lectin Domain Family 6, Member A (CLEC6A)

Autre désignation: CLEC6A (CLEC6A Produits)

Synonymes: anticorps CLEC4N, anticorps CLECSF10, anticorps CLEC6A, anticorps C-type lectin domain containing 6A, anticorps C-type lectin domain family 6, member A, anticorps CLEC6A, anticorps Clec6a

Sujet:

Description: Binds high-mannose carbohydrates in a Ca2+-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway (By similarity).

Gene: CLEC6A

Poids moléculaire: 24 kDa

ID gène: 93978

UniProt: Q6EIG7