Cyclin C anticorps (C-Term)

N° du produit ABIN6261144

L’anticorps Lapin Polyclonal anti-Cyclin C a été validé pour WB, ELISA, IF et ICC. Il convient pour détecter Cyclin C dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Cyclin C anticorps (C-Term) (ABIN6261144)

Antigène: Cyclin C (CCNC)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cyclin C est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Détail du produit anti-Cyclin C anticorps

Épitope: C-Term

Specificité: Cyclin C Antibody detects endogenous levels of total Cyclin C.

Homologie: Bovine,Horse,Sheep,Rabbit,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human Cyclin C, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur Cyclin C

Antigène: Cyclin C (CCNC)

Autre désignation: CCNC

Sujet:

Description: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.

Gene: CCNC

Poids moléculaire: 33 kDa

ID gène: 892

UniProt: P24863

Pathways: Cycle Cellulaire, Regulation of Lipid Metabolism by PPARalpha