DIS3 anticorps (Internal Region)

N° du produit ABIN6261304

Détail du produit anti-DIS3 anticorps

Antigène: DIS3 (Exosome Complex Exonuclease RRP44 (DIS3))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DIS3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificité: DIS3 Antibody detects endogenous levels of total DIS3.

Homologie: Pig,Zebrafish,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human DIS3, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur DIS3

Antigène: DIS3 (Exosome Complex Exonuclease RRP44 (DIS3))

Autre désignation: DIS3 (DIS3 Produits)

Synonymes: anticorps EXOSC11, anticorps KIAA1008, anticorps RP11-342J4.3, anticorps RRP44, anticorps bA555G22.1, anticorps dis3p, anticorps DIS3, anticorps 2810028N01Rik, anticorps RGD1304646, anticorps wu:fb08g12, anticorps dis3, anticorps DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease, anticorps DIS3 exosome endoribonuclease and 3'-5' exoribonuclease, anticorps DIS3, anticorps Dis3, anticorps dis3, anticorps dis3.L

Sujet:

Description: Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities.

Gene: DIS3

Poids moléculaire: 110 kDa

ID gène: 22894

UniProt: Q9Y2L1