DNAJB2 anticorps (Internal Region)

N° du produit ABIN6261330

Détail du produit anti-DNAJB2 anticorps

Antigène: DNAJB2 (DnaJ (Hsp40) Homolog, Subfamily B, Member 2 (DNAJB2))

Épitope: Internal Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DNAJB2 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: DNAJB2 Antibody detects endogenous levels of total DNAJB2.

Homologie: Pig,Bovine,Horse,Sheep,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human DNAJB2, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur DNAJB2

Antigène: DNAJB2 (DnaJ (Hsp40) Homolog, Subfamily B, Member 2 (DNAJB2))

Autre désignation: DNAJB2 (DNAJB2 Produits)

Synonymes: anticorps MGC78895, anticorps DSMA5, anticorps HSJ-1, anticorps HSJ1, anticorps HSPF3, anticorps 2700059H22Rik, anticorps Dnajb10, anticorps Hsj1, anticorps mDj8, anticorps DnaJ heat shock protein family (Hsp40) member B2 L homeolog, anticorps DnaJ heat shock protein family (Hsp40) member B2, anticorps dnajb2.L, anticorps DNAJB2, anticorps dnajb2, anticorps Dnajb2

Sujet:

Description: Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family (PubMed:7957263, PubMed:22219199). In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins (PubMed:15936278, PubMed:21625540). Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes (PubMed:12754272, PubMed:20889486, PubMed:21719532, PubMed:22396390, PubMed:24023695). Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins (PubMed:15936278).

Gene: DNAJB2

Poids moléculaire: 36 kDa

ID gène: 3300

UniProt: P25686