DNAJC3 anticorps (C-Term)

N° du produit ABIN6261337

Cet anticorps anti-DNAJC3 Polyclonal Lapin (ABIN6261337) détecte spécifiquement DNAJC3 dans ELISA, WB et IHC. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour DNAJC3 anticorps (C-Term) (ABIN6261337)

Antigène: DNAJC3 (DnaJ (Hsp40) Homolog, Subfamily C, Member 3 (DNAJC3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DNAJC3 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-DNAJC3 anticorps

Épitope: C-Term

Specificité: DNAJC3 Antibody detects endogenous levels of total DNAJC3.

Homologie: Pig,Bovine,Horse,Sheep,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human DNAJC3, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur DNAJC3

Antigène: DNAJC3 (DnaJ (Hsp40) Homolog, Subfamily C, Member 3 (DNAJC3))

Autre désignation: DNAJC3

Sujet:

Description: Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity.

Gene: DNAJC3

Poids moléculaire: 54 kDa

ID gène: 5611

UniProt: Q13217

Pathways: ER-Nucleus Signaling