DNAJC3 anticorps (AA 351-450)

N° du produit ABIN735548

Détail du produit anti-DNAJC3 anticorps

Antigène: DNAJC3 (DnaJ (Hsp40) Homolog, Subfamily C, Member 3 (DNAJC3))

Épitope: AA 351-450

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DNAJC3 est non-conjugé

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Souris, Rat

Homologie: Human,Dog,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human p58ipk/DNAJC3

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-DNAJC3 (ABIN735548)

Taguchi, Allende, Mizukami, Cook, Gavrilova, Tuymetova, Clarke, Chen, Olivera, Proia: "Sphingosine-1-phosphate Phosphatase 2 Regulates Pancreatic Islet β-Cell Endoplasmic Reticulum Stress and Proliferation." dans: The Journal of biological chemistry, Vol. 291, Issue 23, pp. 12029-38, (2016) (PubMed).

Détails sur DNAJC3

Antigène: DNAJC3 (DnaJ (Hsp40) Homolog, Subfamily C, Member 3 (DNAJC3))

Autre désignation: DNAJC3 (DNAJC3 Produits)

Synonymes: anticorps ERdj6, anticorps HP58, anticorps P58, anticorps P58IPK, anticorps PRKRI, anticorps zgc:56356, anticorps zgc:77731, anticorps wu:fb64f06, anticorps DNAJC3, anticorps dnajc3, anticorps DDBDRAFT_0186884, anticorps DDBDRAFT_0233602, anticorps DDB_0186884, anticorps DDB_0233602, anticorps cg8286, anticorps AA408985, anticorps AU067833, anticorps Dnajc3a, anticorps Dnajc3b, anticorps Prkri, anticorps mp58, anticorps p58, anticorps p58IPK, anticorps fc17a06, anticorps prkri, anticorps wu:fc17a06, anticorps DnaJ heat shock protein family (Hsp40) member C3, anticorps DnaJ (Hsp40) homolog, subfamily C, member 3a, anticorps DNAJ heat shock N-terminal domain-containing protein, anticorps DnaJ heat shock protein family (Hsp40) member C3 L homeolog, anticorps DnaJ (Hsp40) homolog, subfamily C, member 3b, anticorps DNAJC3, anticorps dnajc3a, anticorps dnajc3, anticorps dnajc3.L, anticorps Dnajc3, anticorps dnajc3b

Sujet:

Synonyms: DNAJC3, Protein Kinase Inhibitor P58, DnaJ homolog subfamily C member 3, HP58, Interferon induced, double stranded RNA activated protein kinase inhibitor, P58, p58 ipk , P58IPK, PRKRI, Protein kinase inhibitor of 58 kDa, Protein kinase inhibitor p58.

Background: DNAJC3 may act as an inhibitor of both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2/PKR to catalyze phosphorylation of the EIF2A. It also functions as a Co-chaperone of HSPA8/HSC70 and is involved in the unfolded protein response (UPR) during ER stress. It has been reported that this protein stimulates the ATPase activity of HSPA8/HSC70.DNAJC3 is also involved in ativiral defense - it is activated in response to infection by influenza virus through the dissociation of DNAJB1. DNAJC3 is widely expressed and can be found at high levels in the testis and pancreas (expression in cell lines is variable).

ID gène: 5611

UniProt: Q13217

Pathways: ER-Nucleus Signaling