SHFM1 anticorps

N° du produit ABIN6261375

Détail du produit anti-SHFM1 anticorps

Antigène: SHFM1 (Split Hand/foot Malformation (Ectrodactyly) Type 1 (SHFM1))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SHFM1 est non-conjugé

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Specificité: DSS1 antibody detects endogenous levels of DSS1.

Réactivité croisée: Humain, Rat (Rattus)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human DSS1.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C.Stable for 12 months from date of receipt

Date de péremption: 12 months

Détails sur SHFM1

Antigène: SHFM1 (Split Hand/foot Malformation (Ectrodactyly) Type 1 (SHFM1))

Autre désignation: DSS1 (SHFM1 Produits)

Synonymes: anticorps DSS1, anticorps ECD, anticorps SEM1, anticorps SHFD1, anticorps SHSF1, anticorps Shfdg1, anticorps Shfg, anticorps Dss1, anticorps SHFM1, anticorps dss1, anticorps ecd, anticorps sem1, anticorps shfd1, anticorps shfdg1, anticorps shfm1, anticorps shfm1.S, anticorps shsf1, anticorps wu:fb55c02, anticorps zgc:56203, anticorps zgc:85901, anticorps SEM1, 26S proteasome complex subunit, anticorps SEM1, 26S proteasome complex subunit S homeolog, anticorps SEM1, anticorps Sem1, anticorps sem1.S, anticorps sem1

Sujet:

Description: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (PubMed:15117943). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and thus transcription-associated genomic instability. R-loop accumulation increases in SEM1-depleted cells.

Gene: SEM1

Poids moléculaire: 8-10 kDa

ID gène: 7979

UniProt: P60896