HACE1 anticorps (C-Term)
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- Antigène Voir toutes HACE1 Anticorps
- HACE1 (HECT Domain and Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1))
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Épitope
- C-Term
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp HACE1 est non-conjugé
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Application
- ELISA, Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificité
- HACE1 Antibody detects endogenous levels of total HACE1.
- Homologie
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human HACE1, corresponding to a region within C-terminal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product HACE1 Anticorps primaire
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- Indications d'application
- WB 1:1000-3000, IHC 1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- HACE1 (HECT Domain and Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1))
- Autre désignation
- HACE1 (HACE1 Produits)
- Synonymes
- anticorps HACE1, anticorps 1700042J16Rik, anticorps A730034A22Rik, anticorps BC025474, anticorps HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1, anticorps HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 L homeolog, anticorps HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1, anticorps HACE1, anticorps hace1, anticorps hace1.L, anticorps Hace1
- Sujet
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Description: E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.
Gene: HACE1
- Poids moléculaire
- 102 kDa
- ID gène
- 57531
- UniProt
- Q8IYU2
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