MPHOSPH8 anticorps (Internal Region)

N° du produit ABIN6263338

Détail du produit anti-MPHOSPH8 anticorps

Antigène: MPHOSPH8 (M-Phase phosphoprotein 8 (MPHOSPH8))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MPHOSPH8 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: MPHOSPH8 Antibody detects endogenous levels of total MPHOSPH8.

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human MPHOSPH8, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur MPHOSPH8

Antigène: MPHOSPH8 (M-Phase phosphoprotein 8 (MPHOSPH8))

Autre désignation: MPHOSPH8 (MPHOSPH8 Produits)

Synonymes: anticorps HSMPP8, anticorps TWA3, anticorps mpp8, anticorps 1500035L22Rik, anticorps 4930548G07Rik, anticorps AU040635, anticorps Ab2-008, anticorps RGD1305133, anticorps M-phase phosphoprotein 8, anticorps MPHOSPH8, anticorps Mphosph8

Sujet:

Description: Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3 (PubMed:26022416). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites, these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592).

Gene: MPHOSPH8

Poids moléculaire: 97 kDa

ID gène: 54737

UniProt: Q99549