RBBP6 anticorps (Internal Region)

N° du produit ABIN6279764

Détail du produit anti-RBBP6 anticorps

Antigène: RBBP6 (Retinoblastoma Binding Protein 6 (RBBP6))

Épitope: Internal Region

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RBBP6 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: RBBP6 Antibody detects endogenous levels of total RBBP6.

Homologie: Pig,Bovine,Sheep,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human RBBP6, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur RBBP6

Antigène: RBBP6 (Retinoblastoma Binding Protein 6 (RBBP6))

Autre désignation: RBBP6 (RBBP6 Produits)

Synonymes: anticorps MY038, anticorps P2P-R, anticorps PACT, anticorps RBQ-1, anticorps SNAMA, anticorps 4933422O15Rik, anticorps AI316869, anticorps BB233631, anticorps C030034J04Rik, anticorps C77662, anticorps rbbp6, anticorps MGC75882, anticorps RBBP6, anticorps im:7158869, anticorps rbbp6l, anticorps RB binding protein 6, ubiquitin ligase, anticorps retinoblastoma binding protein 6, ubiquitin ligase, anticorps retinoblastoma binding protein 6, anticorps RBBP6, anticorps Rbbp6, anticorps rbbp6

Sujet:

Description: E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53, may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359).

Gene: RBBP6

Poids moléculaire: 202 kDa

ID gène: 5930

UniProt: Q7Z6E9

Pathways: Regulatory RNA Pathways