SMARCA5 anticorps (C-Term)

N° du produit ABIN6265180

Détail du produit anti-SMARCA5 anticorps

Antigène: SMARCA5 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 5 (SMARCA5))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMARCA5 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificité: SMARCA5 Antibody detects endogenous levels of total SMARCA5.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human SMARCA5, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur SMARCA5

Antigène: SMARCA5 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 5 (SMARCA5))

Autre désignation: SMARCA5 (SMARCA5 Produits)

Synonymes: anticorps fb26d12, anticorps fb49g04, anticorps chunp6878, anticorps im:7146484, anticorps wu:fb26d12, anticorps wu:fb49g04, anticorps zgc:158434, anticorps smarca5, anticorps iswi, anticorps SMARCA5, anticorps hiswi, anticorps snf2h, anticorps hsnf2h, anticorps wcrf135, anticorps MGC79455, anticorps ISWI, anticorps SNF2H, anticorps WCRF135, anticorps hISWI, anticorps hSNF2H, anticorps 4933427E24Rik, anticorps D030040M08Rik, anticorps D330027N15Rik, anticorps MommeD4, anticorps Snf2h, anticorps SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5, anticorps SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 S homeolog, anticorps smarca5, anticorps smarca5.S, anticorps SMARCA5, anticorps Smarca5

Sujet:

Description: Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin, this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing.

Gene: SMARCA5

Poids moléculaire: 122kDa

ID gène: 8467

UniProt: O60264

Pathways: Chromatin Binding