SMYD2A anticorps (Internal Region)

N° du produit ABIN6265198

Détail du produit anti-SMYD2A anticorps

Antigène: SMYD2A (SET and MYND Domain Containing 2a (SMYD2A))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMYD2A est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: SMYD2 Antibody detects endogenous levels of total SMYD2.

Homologie: Pig,Bovine,Horse,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human SMYD2, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur SMYD2A

Antigène: SMYD2A (SET and MYND Domain Containing 2a (SMYD2A))

Autre désignation: SMYD2 (SMYD2A Produits)

Synonymes: anticorps HSKM-B, anticorps KMT3C, anticorps ZMYND14, anticorps 1110020E07Rik, anticorps 4930402C15, anticorps Zmynd14, anticorps smyd2-a, anticorps im:7146196, anticorps smyd2, anticorps wu:fc02f02, anticorps zgc:110553, anticorps si:dkey-121j17.3, anticorps zgc:136609, anticorps SET and MYND domain containing 2, anticorps SET and MYND domain containing 2 S homeolog, anticorps SET and MYND domain containing 2a, anticorps SET and MYND domain containing 2b, anticorps SMYD2, anticorps Smyd2, anticorps smyd2.S, anticorps smyd2a, anticorps smyd2b

Sujet:

Description: Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.

Gene: SMYD2

Poids moléculaire: 49 kDa

ID gène: 56950

UniProt: Q9NRG4