TJP3 anticorps (C-Term)

N° du produit ABIN6265590

L’anticorps Lapin Polyclonal anti-TJP3 a été validé pour WB et ELISA. Il convient pour détecter TJP3 dans des échantillons de Humain, Rat et Souris.

Aperçu rapide pour TJP3 anticorps (C-Term) (ABIN6265590)

Antigène: TJP3 (Tight Junction Protein 3 (Zona Occludens 3) (TJP3))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TJP3 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-TJP3 anticorps

Épitope: C-Term

Specificité: TJP3 Antibody detects endogenous levels of total TJP3.

Homologie: Pig,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human TJP3, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur TJP3

Antigène: TJP3 (Tight Junction Protein 3 (Zona Occludens 3) (TJP3))

Autre désignation: TJP3

Sujet:

Description: TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates to the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity).

Gene: TJP3

Poids moléculaire: 101 kDa

ID gène: 27134

UniProt: O95049