RECQL2 anticorps (Internal Region)

N° du produit ABIN6266052

Détail du produit anti-RECQL2 anticorps

Antigène: RECQL2 (WRN) (Werner syndrome RecQ like helicase (WRN))

Épitope: Internal Region

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RECQL2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: WRN Antibody detects endogenous levels of total WRN.

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human WRN, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, IHC 1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur RECQL2

Antigène: RECQL2 (WRN) (Werner syndrome RecQ like helicase (WRN))

Autre désignation: WRN (WRN Produits)

Synonymes: anticorps RECQ3, anticorps RECQL2, anticorps RECQL3, anticorps xBLM, anticorps recq2, anticorps recql2, anticorps recql3, anticorps AI846146, anticorps ffa-1, anticorps xwrn, anticorps RGD1564788, anticorps Werner syndrome RecQ like helicase, anticorps mediator of RNA polymerase II transcription subunit 34, anticorps Bloom syndrome RecQ like helicase, anticorps Werner syndrome, RecQ helicase-like L homeolog, anticorps WRN, anticorps LOC9327212, anticorps blm, anticorps Wrn, anticorps wrn.L

Sujet:

Description: Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers, stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation.

Gene: WRN

Poids moléculaire: 162 kDa

ID gène: 7486

UniProt: Q14191

Pathways: Réparation de l'ADN