TGFB1 anticorps (C-Term)

N° du produit ABIN6266431

Cet anticorps anti-TGFB1 est un anticorps Lapin Polyclonal détectant TGFB1 dans WB, IHC, ELISA, ICC et IF. Adapté pour Humain, Souris et Rat. Ce Primary Antibody a été cité dans 5+ publications.

Aperçu rapide pour TGFB1 anticorps (C-Term) (ABIN6266431)

Antigène: TGFB1 (Transforming Growth Factor, beta 1 (TGFB1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TGFB1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Détail du produit anti-TGFB1 anticorps

Épitope: C-Term

Specificité: TGF beta1 Antibody detects endogenous levels of total TGF beta1.

Homologie: Pig,Bovine,Horse,Sheep,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human TGF beta1, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:50-1:200, IF/ICC 1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Références pour anticorps anti-TGFB1 (ABIN6266431)

Yan, Li, Fan, Du, Ma, Cheng, Li, Zhang, Yu, Wang, Tang, Zheng: "The roles of Toll-like receptor 4 in the pathogenesis of pathogen-associated biliary fibrosis caused by Clonorchis sinensis." dans: Scientific reports, Vol. 7, Issue 1, pp. 3909, (2018) (PubMed).

Xia, Deng, Zhou, Shao, Yang, Sha, Zou: "Expression and significance of Sirt1 in renal allografts at the early stage of chronic renal allograft dysfunction." dans: Transplant immunology, Vol. 48, pp. 18-25, (2018) (PubMed).

Hui, Dingjie, Yuan, Zhongqiu, Na, Mingjian, Yu, Guangyuan, Xuemin, Shifeng, Yucong, Fang, Summer, Hong: "Silicosis decreases bone mineral density in rats." dans: Toxicology and applied pharmacology, Vol. 348, pp. 117-122, (2018) (PubMed).

Zhao, Wu, Chen, Ji, Zheng: "TGF-β1 and connexin-43 expression in neurogenic bladder from rats with sacral spinal cord injury." dans: Neurourology and urodynamics, (2018) (PubMed).

Ai, Liu, Lu, Liang, Sun, Chen, Sun, Li, Liu, Zhang, Liu, Xiao, Jing, Sun, Zhou, Yang: "Phenytoin silver: a new nanocompound for promoting dermal wound healing via comprehensive pharmacological action." dans: Theranostics, Vol. 7, Issue 2, pp. 425-435, (2017) (PubMed).

Détails sur TGFB1

Antigène: TGFB1 (Transforming Growth Factor, beta 1 (TGFB1))

Autre désignation: TGFB1

Sujet:

Description: Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (By similarity). Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysis (RIP) (PubMed:25310401). Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells. Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus (PubMed:25893292). Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types (PubMed:25893292).

Gene: TGFB1

Poids moléculaire: 45kDa

ID gène: 7040

UniProt: P01137

Pathways: EGFR Signaling Pathway, Dopaminergic Neurogenesis, Cellular Response to Molecule of Bacterial Origin, Glycosaminoglycan Metabolic Process, Regulation of Leukocyte Mediated Immunity, Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Ribonucleoside Biosynthetic Process, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus, Autophagy, Cancer Immune Checkpoints