CMKLR1 anticorps (Internal Region)

N° du produit ABIN6281934

Détail du produit anti-CMKLR1 anticorps

Antigène: CMKLR1 (Chemokine-Like Receptor 1 (CMKLR1))

Épitope: AA 190-270, Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CMKLR1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: ChemR23 is a protein encoded by the CMKLR1 gene which is approximately 42,3 kDa. ChemR23 is localised to the cell membrane. It is involved in the peptide ligand-binding receptors and is a receptor for the chemo-attractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 also induces activation of intracellular signalling molecules. ChemR23 is prominently expressed in developing osseous and cartilaginous tissue. Mutations in the CMKLR1 gene may result in Cataract and Alzheimer's disease. STJ92262 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of ChemR23 protein.

Specificité: ChemR23 Polyclonal Antibody detects endogenous levels of ChemR23 protein.

Attributs du produit: Rabbit polyclonal to ChemR23.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from human ChemR23

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:20000

Commentaires:

Prominently expressed in developing osseous and cartilaginous tissue. Also found in adult parathyroid glands. Expressed in cardiovascular system, brain, kidney, gastrointestinal tissues and myeloid tissues. Expressed in a broad array of tissues associated with hematopoietic and immune function including, spleen, thymus, appendix, lymph node, bone marrow and fetal liver. Among leukocyte populations abundant expression in monocyte-derived macrophage and immature dendritic cells (DCs). High expression in blood monocytes and low levels in polymorphonuclear cells and T-cells. Expressed on endothelial cells. Highly expressed in differentiating adipocytes.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C, and avoid repeat freeze-thaw cycles.

Détails sur CMKLR1

Antigène: CMKLR1 (Chemokine-Like Receptor 1 (CMKLR1))

Autre désignation: ChemR23 (CMKLR1 Produits)

Synonymes: anticorps CHEMERINR, anticorps ChemR23, anticorps DEZ, anticorps RVER1, anticorps Gpcr27, anticorps mcmklr1, anticorps si:ch211-240b21.3, anticorps CMLKR1, anticorps Cmklr-1, anticorps GPCR, anticorps chemerin chemokine-like receptor 1, anticorps chemokine-like receptor 1, anticorps CMKLR1, anticorps Cmklr1, anticorps cmklr1

Poids moléculaire: 42 kDa

ID gène: 1240

UniProt: Q99788