Kv2.1/KCNB1 anticorps (AA 510-590)

N° du produit ABIN6284347

Détail du produit anti-Kv2.1/KCNB1 anticorps

Antigène: Kv2.1/KCNB1 (KCNB1) (Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 (KCNB1))

Épitope: AA 510-590

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Kv2.1/KCNB1 est non-conjugé

Application: ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: Kv2.1 is a protein encoded by the KCNB1 gene which is approximately 95,8 kDa. Kv2.1 is localised to the cell membrane. It is involved in integration of energy metabolism, potassium channels and aquaporin-mediated transport. It contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and also plays a role in homeostatic attenuation of electrical excitability throughout the brain. Kv2.1 is expressed in the brain, heart, lung, liver, colon, kidney and adrenal gland. Mutations in the KCNB1 gene may result in epileptic encephalopathy. STJ93873 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Kv2.1 protein.

Specificité: Kv2.1 Polyclonal Antibody detects endogenous levels of Kv2.1 protein.

Attributs du produit: Rabbit polyclonal to Kv2.1.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from human Kv2.1 around the non-phosphorylation site of S567.

Isotype: IgG

Information d'application

Indications d'application: IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:20000

Commentaires:

Expressed in neocortical pyramidal cells . Expressed in pancreatic beta cells (at protein level) . Expressed in brain, heart, lung, liver, colon, kidney and adrenal gland . Expressed in the cortex, amygdala, cerebellum, pons, thalamus, hypothalamus, hippocampus and substantia nigra .

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C, and avoid repeat freeze-thaw cycles.

Détails sur Kv2.1/KCNB1

Antigène: Kv2.1/KCNB1 (KCNB1) (Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 (KCNB1))

Autre désignation: Kv2.1 (KCNB1 Produits)

Synonymes: anticorps KCNB1, anticorps Kcnb1, anticorps Kcr1-1, anticorps Kv2.1, anticorps Shab, anticorps DRK1PC, anticorps DRK1, anticorps KV2.1, anticorps h-DRK1, anticorps potassium voltage-gated channel subfamily B member 1, anticorps potassium voltage-gated channel, Shab-related subfamily, member 1, anticorps potassium channel, voltage gated Shab related subfamily B, member 1, anticorps potassium voltage gated channel, Shab-related subfamily, member 1, anticorps KCNB1, anticorps kcnb1, anticorps LOC100541632, anticorps Kcnb1

Poids moléculaire: 90 kDa

ID gène: 3745

UniProt: Q14721

Pathways: Synaptic Membrane