beta-2 Microglobulin anticorps

N° du produit ABIN6296700

Cet anticorps anti-beta-2 Microglobulin Monoclonal Souris (ABIN6296700) détecte spécifiquement beta-2 Microglobulin dans FACS, IF, IP et IHC (fro). L’anticorps est réactif avec des échantillons de Humain et Non-Human Primate.

Aperçu rapide pour beta-2 Microglobulin anticorps (ABIN6296700)

Antigène: beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

Reactivité: Humain, Non-Human Primate

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp beta-2 Microglobulin est non-conjugé

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-beta-2 Microglobulin anticorps

Fonction: Mouse anti-Human/non-Human primates Beta-2 Microglobulin Antibody [Sodium Azide Free]

Specificité: Cytoplasmic

Purification: MOLT-4 human T cell line was used as the immunogen for the Beta-2 Microglobulin antibody.

Immunogène: MOLT-4 human T cell line was used as the immunogen for the Beta-2 Microglobulin antibody.

Information d'application

Indications d'application: Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 0.5-1 μg/mL
Immunoprecipitation: 2 μg/mg of lysate
Immunohistochemistry (Frozen): 0.5-1 μg/mL for 30 min at RT

Restrictions: For Research Use only

Stockage

Buffer: In 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Détails sur beta-2 Microglobulin

Antigène: beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

Autre désignation: Beta-2-microglobulin

Sujet:

Target Description: Recognizes a protein of 12 kDa, identified as microglobulin. Major histocompatibility complex (MHC) class 1 Molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 Molecules consist of an alpha- heavy chain that contains three subdomains (alpha-1, alpha-2, alpha-3) and a non-covalent associating light chain, known as beta-2-Microglobulin. Beta-2-Microglobulin associates with the alpha-3 subdomain of the alpha- heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 Molecules. The alpha-1 and alpha-2 domains of the alpha- heavy chain form the peptide antigen-binding cleft. Mutations in the beta-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.

Gene Symbol: B2M///CDABP0092///HDCMA22P

ID gène: 567

UniProt: P61769

Pathways: TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process