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Presenilin 2 anticorps

PSEN2 Reactivité: Humain, Rat, Souris, Chien WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN634258
  • Antigène Voir toutes Presenilin 2 (PSEN2) Anticorps
    Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))
    Reactivité
    • 59
    • 41
    • 32
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain, Rat, Souris, Chien
    Hôte
    • 49
    • 4
    • 3
    • 2
    • 1
    Lapin
    Clonalité
    • 54
    • 5
    Polyclonal
    Conjugué
    • 35
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Presenilin 2 est non-conjugé
    Application
    • 48
    • 19
    • 13
    • 12
    • 11
    • 10
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Purification
    Affinity purified
    Immunogène
    Presenilin 2 antibody was raised using a synthetic peptide corresponding to a region with amino acids VVVATIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIV
    Top Product
    Discover our top product PSEN2 Anticorps primaire
  • Indications d'application
    WB: 1 µg/mL, IHC: 4-8 µg/mL
    Optimal conditions should be determined by the investigator.
    Commentaires

    Presenilin 2 Blocking Peptide, catalog no. 33R-9902, is also available for use as a blocking control in assays to test for specificity of this Presenilin 2 antibody

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Lyophilized powder. Add distilled water for a 1 mg/mL concentration of PSEN2 antibody in PBS
    Concentration
    Lot specific
    Buffer
    PBS
    Conseil sur la manipulation
    Avoid repeated freeze/thaw cycles.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.
  • Antigène
    Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))
    Autre désignation
    Presenilin 2 (PSEN2 Produits)
    Synonymes
    anticorps AD3L, anticorps AD4, anticorps CMD1V, anticorps PS2, anticorps STM2, anticorps ALG-3, anticorps Ad4h, anticorps Alg3, anticorps PS-2, anticorps Psnl2, anticorps pre2, anticorps zf-PS2, anticorps PSNL2, anticorps PSEN2, anticorps ad4, anticorps ps2, anticorps ad3l, anticorps stm2, anticorps Ps2, anticorps presenilin 2, anticorps presenilin 2 S homeolog, anticorps presenilin 2 (Alzheimer disease 4), anticorps trefoil factor 1, anticorps PSEN2, anticorps Psen2, anticorps psen2, anticorps psen2.S, anticorps Tff1
    Sujet
    Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes.
    Poids moléculaire
    49 kDa (MW of target protein)
    Pathways
    Signalisation Notch, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
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