CRH anticorps (C-Term)

N° du produit ABIN655191

Détail du produit anti-CRH anticorps

Antigène: CRH (Corticotropin Releasing Hormone (CRH))

Épitope: AA 129-156, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CRH est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This CRH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 129-156 amino acids from the C-terminal region of human CRH.

Clone: RB23963

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Détails sur CRH

Antigène: CRH (Corticotropin Releasing Hormone (CRH))

Autre désignation: CRH (CRH Produits)

Synonymes: anticorps CRF, anticorps Gm1347, anticorps crf, anticorps crh, anticorps zgc:101864, anticorps CRH, anticorps corticoliberin, anticorps crhb, anticorps crh.1-a, anticorps crha, anticorps corticotropin releasing hormone, anticorps corticotropin releasing hormone b, anticorps corticotropin releasing hormone S homeolog, anticorps corticotropin releasing hormone L homeolog, anticorps Crh, anticorps CRH, anticorps crhb, anticorps crh, anticorps crh.S, anticorps crh.L

Sujet: Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition.

Poids moléculaire: 21422

ID gène: 1392

NCBI Accession: NP_000747

UniProt: P06850

Pathways: Positive Regulation of Peptide Hormone Secretion, Hormone Activity, Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Feeding Behaviour