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Caspase 8 anticorps

CASP8 Reactivité: Humain, Souris, Rat WB, IHC, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6566506
  • Antigène Voir toutes Caspase 8 (CASP8) Anticorps
    Caspase 8 (CASP8)
    Reactivité
    • 139
    • 70
    • 63
    • 23
    • 16
    • 16
    • 10
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 130
    • 26
    • 6
    • 2
    Lapin
    Clonalité
    • 127
    • 36
    Polyclonal
    Conjugué
    • 99
    • 16
    • 11
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp Caspase 8 est non-conjugé
    Application
    • 144
    • 50
    • 44
    • 39
    • 27
    • 26
    • 25
    • 21
    • 20
    • 18
    • 8
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    Purification
    Affinity purification
    Immunogène
    Recombinant fusion protein of human Caspase-8 (NP_001073593.1).
    Isotype
    IgG
    Top Product
    Discover our top product CASP8 Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Avoid freeze / thaw cycles.
  • Antigène
    Caspase 8 (CASP8)
    Autre désignation
    Caspase-8 (CASP8 Produits)
    Synonymes
    anticorps casp8-A, anticorps xCaspase-8, anticorps casp8, anticorps CASP8, anticorps CASP-8, anticorps FLICE, anticorps MACH, anticorps Mch5, anticorps ALPS2B, anticorps CAP4, anticorps Casp-8, anticorps MCH5, anticorps caspase-8, anticorps zgc:92075, anticorps caspase 8 L homeolog, anticorps death related ced-3/Nedd2-like protein, anticorps caspase 8, anticorps caspase-8, anticorps caspase-8-like, anticorps caspase 8, apoptosis-related cysteine peptidase, anticorps casp8.L, anticorps LOC661095, anticorps CASP8, anticorps LOC5563818, anticorps casp8, anticorps LOC100222284, anticorps Casp8
    Sujet
    This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.
    Poids moléculaire

    Observed_MW: 17kDa, 44kDa, 60kDa

    Calculated_MW: 25-32kDa/45- 61kDa

    ID gène
    841
    UniProt
    Q14790
    Pathways
    Apoptose, Caspase Cascade in Apoptosis, Signalisation TLR, Activation of Innate immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades
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