AF4 anticorps
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- Antigène Tous les produits AF4 (AFF1)
- AF4 (AFF1) (AF4/FMR2 Family, Member 1 (AFF1))
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Reactivité
- Humain, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp AF4 est non-conjugé
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Application
- Immunofluorescence (IF)
- Purification
- Affinity purification
- Immunogène
- Recombinant fusion protein of human AFF1 (NP_001160165.1).
- Isotype
- IgG
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- Indications d'application
- IF 1:50-1:100
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Avoid freeze / thaw cycles.
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- Antigène
- AF4 (AFF1) (AF4/FMR2 Family, Member 1 (AFF1))
- Autre désignation
- AFF1 (AFF1 Produits)
- Synonymes
- anticorps AF4, anticorps MLLT2, anticorps PBM1, anticorps 9630032B01Rik, anticorps AW319193, anticorps Af4, anticorps Mllt2h, anticorps Rob, anticorps Mllt2, anticorps AF4/FMR2 family member 1, anticorps AF4/FMR2 family, member 1, anticorps AFF1, anticorps Aff1
- Sujet
- This gene encodes a member of the AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome family of proteins, which have been implicated in childhood lymphoblastic leukemia, Fragile X E site mental retardation, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in multiple transcript variants.
- Poids moléculaire
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Observed_MW: Refer to figures
Calculated_MW: 131kDa/132kDa
- ID gène
- 4299
- UniProt
- P51825
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