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AF4 anticorps (AF4/FMR2 Family, Member 1) Primary Antibody

AFF1 Reactivité: Humain IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6570791
$438.90
Plus shipping costs $45.00
200 μL ABIN6570791
200 μL ABIN6570791
local_shipping Destination: Etats-Unis
Envoi sous 9 à 11 jours ouvrables
  • Antigène
    AF4 (AFF1)
    Reactivité
    Humain
    • 51
    • 21
    • 17
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Hôte
    Lapin
    Clonalité
    Polyclonal
    Conjugué
    Cet anticorp AF4 est non-conjugé
    • 23
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Application
    Immunofluorescence (IF)
    • 31
    • 21
    • 13
    • 10
    • 8
    • 2
    • 2
    • 1
    • 1
    • 1
    Purification
    Affinity purification
    Immunogène
    Recombinant protein of human AFF1
    Isotype
    IgG
  • Indications d'application
    IF 1:50 - 1:100
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Avoid freeze / thaw cycles.
  • Antigène
    AF4 (AFF1)
    Autre désignation
    AFF1 ()
    Synonymes
    AF4, MLLT2, PBM1, 9630032B01Rik, AW319193, Af4, Mllt2h, Rob, Mllt2, AF4/FMR2 family member 1, AF4/FMR2 family, member 1, AFF1, Aff1
    Sujet

    Synonyms: AF 4,AF 4 protein,AF4,AF4-MLL,AF4/FMR2 family member 1,AFF 1,AFF1,AFF1,ALL1 fused gene from chromosome 4,ALL1-fused gene from chromosome 4 protein,FEL,MGC134969,MLL/AF4,MLLT2,myeloid/lymphoid or mixed lineage leukemia (trithorax homolog, Drosophila), translocated to, 2,MYELOID/LYMPHOID OR MIXED LINEAGE LEUKEMIA TRANSLOCATED TO 2, MLLT2,PBM1,Pre B cell monocytic leukemia partner 1,Protein AF-4,Protein FEL,Proto-oncogene AF4

    Background: This gene encodes a member of the AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome family of proteins, which have been implicated in childhood lymphoblastic leukemia, Fragile X E site mental retardation, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in multiple transcript variants.

    Poids moléculaire

    Observed_MW: Refer to figures

    Calculated_MW: 131kDa/132kDa

    ID gène
    4299
    UniProt
    P51825
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