PRKAA2 anticorps

N° du produit ABIN659096

L’anticorps anti-PRKAA2 Monoclonal Souris est utilisé pour la détection de PRKAA2 dans des échantillons de Humain. Il a été validé pour WB et IF.

Aperçu rapide pour PRKAA2 anticorps (ABIN659096)

Antigène: PRKAA2 (Protein Kinase, AMP-Activated, alpha 2 Catalytic Subunit (PRKAA2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PRKAA2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: 206CT5-4-2

Détail du produit anti-PRKAA2 anticorps

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogène: This PRKAA2 monoclonal antibody is generated from mouse immunized with PRKAA2 recombinant protein.

Isotype: IgG2a kappa

Information d'application

Indications d'application: IF: 1:10~50. WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Détails sur PRKAA2

Antigène: PRKAA2 (Protein Kinase, AMP-Activated, alpha 2 Catalytic Subunit (PRKAA2))

Autre désignation: PRKAA2

Sujet: The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.

Poids moléculaire: 62320

ID gène: 5563

NCBI Accession: NP_006243

UniProt: P54646

Pathways: AMPK Signaling, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Carbohydrate Metabolic Process, L'effet Warburg