CYP17A1
Reactivité: Humain
WB
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
Optimal dilution of the Cyp17a1 antibody should be determined by the researcher.\. Western blot: 0.5-1 μg/mL,Immunohistochemistry (FFPE): 1-2 μg/mL,Direct ELISA: 0.1-0.5 μg/mL (recombinant mouse protein)
Restrictions
For Research Use only
Buffer
0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
Stock
-20 °C
Stockage commentaire
After reconstitution, the Cyp17a1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Antigène
CYP17A1
(Cytochrome P450, Family 17, Subfamily A, Polypeptide 1 (CYP17A1))
anticorps cyp17, anticorps CYPXVII, anticorps P450c17, anticorps cyp17a1, anticorps P450-C17, anticorps wu:fi13g04, anticorps wu:fi17b11, anticorps wu:fi31c08, anticorps zgc:136516, anticorps zgc:66494, anticorps P45017A1, anticorps CYP17, anticorps CPT7, anticorps P450C17, anticorps S17AH, anticorps Cyp17, anticorps p450c17, anticorps cytochrome P450 17A1, anticorps cytochrome P450, family 17, subfamily A, polypeptide 1, anticorps steroidogenic cytochrome P450 17-hydroxylase/lyase, anticorps cytochrome P450 family 17 subfamily A member 1 L homeolog, anticorps cytochrome P450 family 17 subfamily A member 1, anticorps cytochrome P-450 17 alpha-hydroxylase/C17,20-lyase, anticorps cytochrome P450, family 17, subfamily a, polypeptide 1, anticorps cytochrome P450c17, anticorps CpipJ_CPIJ010537, anticorps CpipJ_CPIJ010543, anticorps PTRG_02047, anticorps cyp17a1, anticorps cyp17, anticorps cyp17a1.L, anticorps CYP17A1, anticorps Cyp17a1
Sujet
Cytochrome P450 17A1, also called steroid 17-alpha-monooxygenase, is an enzyme of the hydroxylase type that in humans is encoded by the CYP17A1 gene on chromosome 10. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia.