IGFBP2 anticorps (AA 35-304)

N° du produit ABIN6654166

Détail du produit anti-IGFBP2 anticorps

Antigène: IGFBP2 (Insulin-Like Growth Factor Binding Protein 2, 36kDa (IGFBP2))

Épitope: AA 35-304

Reactivité: Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IGFBP2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity purified

Immunogène: Rat IGFBP2 recombinant protein (amino acids E35-Q304) was used as the immunogen for the IGFBP2 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the IGFBP2 antibody should be determined by the researcher.\. Western blot: 0.5-1 μg/mL,Immunohistochemistry (FFPE): 1-2 μg/mL,Direct ELISA: 0.1-0.5 μg/mL (recombinant rat protein)

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the IGFBP2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur IGFBP2

Antigène: IGFBP2 (Insulin-Like Growth Factor Binding Protein 2, 36kDa (IGFBP2))

Autre désignation: IGFBP2 (IGFBP2 Produits)

Synonymes: anticorps IBP2, anticorps IGF-BP53, anticorps AI255832, anticorps IBP-2, anticorps Igfbp-2, anticorps mIGFBP-2, anticorps IGFBP-2, anticorps ILGFBPA, anticorps pIGFBP-2, anticorps igfbp2, anticorps MGC65741, anticorps MGC76823, anticorps MGC174445, anticorps IGFBP2, anticorps ibp2, anticorps igf-bp53, anticorps igfbp2a, anticorps si:ch211-2k18.3, anticorps insulin like growth factor binding protein 2, anticorps insulin-like growth factor binding protein 2, anticorps insulin-like growth factor binding protein 2a, anticorps insulin-like growth factor binding protein 2b, anticorps IGFBP2, anticorps Igfbp2, anticorps igfbp2a, anticorps igfbp2, anticorps igfbp2b

Sujet: The superfamily of insulin-like growth factor (IGF) binding proteins include the six high-affinity IGF binding proteins (IGFBP) and at least four additional low-affinity binding proteins referred to as IGFBP related proteins (IGFBP-rP). All IGFBP superfamily members are cysteine-rich proteins with conserved cysteine residues, which are clustered in the amino- and carboxy-terminal thirds of the molecule. IGFBPs modulate the biological activities of IGF proteins. Some IGFBPs may also have intrinsic bioactivity that is independent of their ability to bind IGF proteins. Post-translational modifications of IGFBPs, including glycosylation, phosphorylation and proteolysis, have been shown to modify the affinities of the binding proteins to IGF. Human IGFBP-2 cDNA encodes a 328 amino acid (aa) residue precursor protein with a putative 39 aa residue signal peptide that is processed to generate the 289 aa residue mature protein. IGFBP-2 contains an integrin receptor recognition sequence (RGD sequence) but lacks potential N-linked glycosylation sites. During development, IGFBP-2 is expressed in a number of tissues. The highest expression level is found in the central nervous system. In adults, high expression levels are also detected in the central nervous system and in a number of reproductive tissues. IGFBP-2 binds preferentially to IGF II, exhibiting a 2-10 fold higher affinity for IGF II than for IGF I.

UniProt: P12843

Pathways: Myometrial Relaxation and Contraction, Growth Factor Binding, Activated T Cell Proliferation