ATF2 anticorps (pSer490, pSer498)

N° du produit ABIN6655069

N° du produit (Fournisseur): 609-401-d11

L’anticorps anti-ATF2 Polyclonal Lapin est utilisé pour la détection de ATF2 dans des échantillons de Humain. Il a été validé pour WB, IHC et ELISA.

Aperçu rapide pour ATF2 anticorps (pSer490, pSer498) (ABIN6655069)

Antigène: ATF2 (Activating Transcription Factor 2 (ATF2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATF2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-ATF2 anticorps

Épitope: pSer490, pSer498

N° du produit (Fournisseur): 609-401-d11

Fournisseur: Rockland

Fonction: ATF2 phospho S490/phospho S498 Antibody

Réactivité croisée (Details): Anti-ATF2 pS490/pS498 Antibody is directed against ATF2 protein phosphorylated at S490/pS498.

Purification: The antibody was prepared from monospecific antiserum by immunoaffinity chromatography using phospho peptide coupled to agarose beads followed by solid phase adsorption(s) against non-phospho peptide and non-specific peptide to remove any unwanted reactivities.

Immunogène: Anti-ATF2 pS490/pS498 Antibody was produced by repeated immunizations with synthetic phospho-peptide corresponding to amino acid residues surrounding Ser490/498.

Isotype: IgG

Information d'application

Indications d'application:

ELISA_Dilution: 1:10,000

Immunohistochemistry_Dilution: 1:1000

Western_Blot_Dilution: 1:1000

Commentaires:

Anti-ATF2 pS490/pS498 antibody is tested for use in ELISA, Western Blotting and IHC. Specific conditions for reactivity should be optimized by the end user. ATF2 antibody is specific for the approximately 74kDa ATF2 protein phosphorylated at Ser490,498. Anti-ATF2 also recognizes the phosphorylated 54kDa splice form of ATF2.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Stock: 4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Date de péremption: 12 months

Détails sur ATF2

Antigène: ATF2 (Activating Transcription Factor 2 (ATF2))

Autre désignation: ATF2

Sujet:

Synonyms: rabbit anti-ATF2 pS490/pS498 Antibody, Cyclic AMP-dependent transcription factor ATF-2, Activating transcription factor 2, Cyclic AMP-responsive element-binding protein 2, CREB-2, HB16, cAMP response element-binding protein CRE-BP1

Background: ATF2 antibody recognizes the activating transcription factor ATF2 (also called CRE-BP1) which binds to both AP-1 and CRE DNA response elements and is a member of the ATF/CREB family of leucine zipper proteins. ATF2 has been implicated in the transcriptional regulation of a number of genes including cytokines, cell cycle control and apoptosis. Various forms of cellular stress, including inflammatory cytokines and UV irradiation, stimulate the transcriptional activity of ATF2. Stress induced ATF-dependent transcription is dependent on phosphorylation of ATF. Serine 490 and serine 498 are novel phosphorylation sites on ATF that have recently been identified. ATF2 is particularly abundant in the brain and the ATF2 family of transcription factors is considered an important substrate of signals upstream of the activation of genes associated with neuronal growth and differentiation. ATF expression has also been linked to the depression in humans. Anti-ATF2 pS490/pS498 antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research.

Gene Name: ATF2

ID gène: 1386

UniProt: P15336

Pathways: Signalisation MAPK, Signalisation RTK, Thyroid Hormone Synthesis, Activation of Innate immune Response, Chromatin Binding, Myometrial Relaxation and Contraction, Synaptic Membrane, Tube Formation, Toll-Like Receptors Cascades