DLG3 anticorps (N-Term)

N° du produit ABIN6658117

Détail du produit anti-DLG3 anticorps

Antigène: DLG3 (Discs, Large Homolog 3 (DLG3))

Épitope: N-Term

Reactivité: Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp DLG3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Réactivité croisée: Humain, Souris, Rat (Rattus)

Purification: Anti-SAP102 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with SAP102 from Human, Mouse, and Rat based on 100% homology with the immunizing sequence. No cross-reactivity against PSD95, SAP97 or Chapsyn-110. Cross-reactivity with SAP102 from other sources has not been determined. Organelle Markers, Neurobiology research.

Immunogène:

Immunogen: SAP102 Antibody was produced in mice by repeated immunizations raised against a fusion protein corresponding to an n-terminal region of rat SAP102.

Immunogen Type: Recombinant Protein

Clone: S19-2

Isotype: IgG1

Information d'application

Indications d'application:

Immunohistochemistry Dilution: User Optimized

Application Note: Anti-SAP102 Antibody is suitable for WB, IP, and IHC. Expect a band approximately 105 kDa protein, corresponding to the molecular mass of SAP102 on SDS Page immunoblots. Specific conditions for reactivity should be optimized by the end user.

Immunoprecipitation Dilution: User Optimized

Western Blot Dilution: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 50 % (v/v) Glycerol

0.09 % (w/v) Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: RT,4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Détails sur DLG3

Antigène: DLG3 (Discs, Large Homolog 3 (DLG3))

Autre désignation: SAP102 (DLG3 Produits)

Synonymes: anticorps MRX, anticorps MRX90, anticorps NEDLG, anticorps SAP102, anticorps XLMR, anticorps DLG3, anticorps fa66c08, anticorps fa66e02, anticorps fd02c12, anticorps fu95c12, anticorps im:7138640, anticorps si:ch211-276g21.1, anticorps wu:fa66c08, anticorps wu:fa66e02, anticorps wu:fd02c12, anticorps wu:fu95c12, anticorps Dlgh3, anticorps mKIAA1232, anticorps MPP3, anticorps 6430514B01, anticorps CSG18, anticorps Dlg3, anticorps Dusp3, anticorps discs large MAGUK scaffold protein 3, anticorps membrane palmitoylated protein 3, anticorps discs, large homolog 3 (Drosophila), anticorps membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3), anticorps DLG3, anticorps MPP3, anticorps dlg3, anticorps Dlg3, anticorps Mpp3

Sujet:

Synonyms: DLG3, MRX90, NEDLG, XLMR, Disks large homolog 3, PSD-95/SAP90-related protein 1, Synapse-associated protein 102, SAP-102

Background: Synapse-associated protein 102 belongs to the membrane-associated guanylate kinase protein family and is a homolog of the Drosophila dis large tumor suppressor protein. SAP102 has extensive sequence homology to the PSD 95 family of proteins that facilitate ion channel clustering at synaptic terminal. SAP102 consists of three 90 amino acids PDZ domains at its amino terminus, a Src homolgy 3 domain and a guanylate kinase domain. All three PDZ domains of SAP102 participate in binding to the NMDA reception, interacting specifically with the carboxy-terminal domain of the N-methyl-D-aspartate receptor 2B (NR2B). The interaction may facilitate AMPA receptor withdrawal from the postsynaptic membrane by inhibiting the ERK/MAPK pathway. SAP102 also interacts with synaptic ras-GTPase activating protein synGAP through its PDZ domains. In general, the SAP102 protein is more highly expressed in non-proliferating cells than in proliferating cells, indicating a role in the negative regulation of cell growth.

Gene Name: Dlg3

ID gène: 58948

NCBI Accession: NP_113827

UniProt: Q62936