GABRB3 anticorps (Cytoplasmic Loop)

N° du produit ABIN6658225

Détail du produit anti-GABRB3 anticorps

Antigène: GABRB3 (gamma-aminobutyric Acid (GABA) A Receptor, beta 3 (GABRB3))

Épitope: Cytoplasmic Loop

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GABRB3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Réactivité croisée: Souris, Rat (Rattus)

Réactivité croisée (Details): Cross reactivity with GABA(A) Receptor beta 3 from other species has not been determined.

Purification: Anti-GABA(A) Receptor beta 3 Antibody is directed against rat GABA(A) Receptor beta 3. The antibody was affinity purified from monospecific antiserum by immunoaffinity purification. Reactivity is expected from the following species based on 100% sequence homology: mouse.

Immunogène:

Immunogen: Anti-GABA(A) Receptor beta 3 Antibody was produced by repeated immunizations with recombinant fusion protein from the cytoplasmic loop of the beta 3 subunit.

Immunogen Type: Recombinant Protein

Isotype: IgG

Information d'application

Indications d'application:

Immunohistochemistry Dilution: User Optimized

Application Note: Anti-GABA(A) Receptor beta 3 (Rabbit) antibody suitable for use in Western Blotting and Immunohistochemistry. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 53 kDa in size corresponding to the beta 3 subunit of GABA A receptor in the appropriate cell lysate or extract.

Western Blot Dilution: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Stock: 4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening. This product is stable at 4° C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Détails sur GABRB3

Antigène: GABRB3 (gamma-aminobutyric Acid (GABA) A Receptor, beta 3 (GABRB3))

Autre désignation: GABA(A) Receptor beta 3 (GABRB3 Produits)

Synonymes: anticorps GABRB3, anticorps eca5, anticorps LOC100230475, anticorps ECA5, anticorps A230092K12Rik, anticorps AW049585, anticorps Cp1, anticorps Gabrb-3, anticorps beta3, anticorps gamma-aminobutyric acid type A receptor beta3 subunit, anticorps gamma-aminobutyric acid (GABA) A receptor, beta 3, anticorps gamma-aminobutyric acid type A receptor beta 3 subunit, anticorps gamma-aminobutyric acid (GABA) A receptor, subunit beta 3, anticorps GABRB3, anticorps gabrb3, anticorps Gabrb3

Sujet:

Synonyms: Gamma-aminobutyric acid receptor subunit beta-3, GABA(A) receptor subunit beta-3, Gabrb3

Background: Anti-GABA(A) Receptor beta 3 Antibody detects GABA(A) Receptor beta 3. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six αs, four βs and four γs, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for α- and β-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a γ-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different α-subunits of the receptor. GABA(A) receptor beta 3 antibody is ideal for investigators involved in Neuroscience.

Gene Name: GABRB3

ID gène: 24922

NCBI Accession: NP_058761

UniProt: P63079

Pathways: Sensory Perception of Sound