PCSK2 anticorps (AA 351-400)

N° du produit ABIN6746608

Détail du produit anti-PCSK2 anticorps

Antigène: PCSK2 (Proprotein Convertase Subtilisin/kexin Type 2 (PCSK2))

Épitope: AA 351-400

Reactivité: Humain, Souris, Rat, Poisson zèbre (Danio rerio), Boeuf (Vache), Chien, Cobaye, Cheval, Lapin, Singe, Poulet, Porc, Roussette (Chauve-souris), Xenopus laevis

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PCSK2 est non-conjugé

Application: Western Blotting (WB)

Specificité: Human PCSK2

Homologie: Percent identity by BLAST analysis: Human, Mouse, Dog, Bovine, Rabbit, Horse, Guinea pig, Chicken, Xenopus, Zebrafish (100%) Pig (92%).

Purification: Immunoaffinity purified

Immunogène: Synthetic peptide located between aa351-400 of human PCSK2 (Q5REC2, NP_002585). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey, Galago, Marmoset, Mouse, Rat, Elephant, Dog, Bovine, Bat, Rabbit, Horse, Pig, Opossum, Guinea pig, Turkey, Chicken, Platypus, Lizard, Xenopus, Frog, Salmon, Stickleback, Medaka, Zebrafish (100%).

Type of Immunogen: Synthetic peptide

Information d'application

Indications d'application: Approved: WB (0.2 - 1 μg/mL)

Usage: Western Blot: Suggested dilution at 1 μg/mL in 5 % skim milk / PBS buffer, and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50,000 - 100,000 as secondary antibody.

Commentaires:

Target Species of Antibody: Human

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Distilled water

Concentration: Lot specific

Buffer: Lyophilized from PBS with 2 % sucrose

Conseil sur la manipulation: Avoid repeat freeze-thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire: Long term: -20°C, the use of 50% glycerol is recommended if storing aliquots in -20°C for long term use (up to 1 year)
Short term (less than 1 week): 4°C. Avoid freeze-thaw cycles.

Références pour anticorps anti-PCSK2 (ABIN6746608)

Discher, Bishopric, Wu, Peterson, Webster: "Hypoxia regulates beta-enolase and pyruvate kinase-M promoters by modulating Sp1/Sp3 binding to a conserved GC element." dans: The Journal of biological chemistry, Vol. 273, Issue 40, pp. 26087-93, (1998) (PubMed).

Feo, Antona, Barbieri, Passantino, Calì, Giallongo: "Transcription of the human beta enolase gene (ENO-3) is regulated by an intronic muscle-specific enhancer that binds myocyte-specific enhancer factor 2 proteins and ubiquitous G-rich-box binding factors." dans: Molecular and cellular biology, Vol. 15, Issue 11, pp. 5991-6002, (1995) (PubMed).

Giallongo, Venturella, Oliva, Barbieri, Rubino, Feo: "Structural features of the human gene for muscle-specific enolase. Differential splicing in the 5'-untranslated sequence generates two forms of mRNA." dans: European journal of biochemistry / FEBS, Vol. 214, Issue 2, pp. 367-74, (1993) (PubMed).

Détails sur PCSK2

Antigène: PCSK2 (Proprotein Convertase Subtilisin/kexin Type 2 (PCSK2))

Autre désignation: PCSK2 (PCSK2 Produits)

Synonymes: anticorps NEC 2, anticorps NEC-2, anticorps NEC2, anticorps PC2, anticorps SPC2, anticorps PCSK2, anticorps 6330411F23Rik, anticorps AI839700, anticorps Nec-2, anticorps Nec2, anticorps Phpp-2, anticorps pc2, anticorps nec2, anticorps spc2, anticorps pcsk2, anticorps pcsk2-A, anticorps proprotein convertase subtilisin/kexin type 2, anticorps proprotein convertase subtilisin/kexin type 2 L homeolog, anticorps PCSK2, anticorps pcsk2, anticorps Pcsk2, anticorps pcsk2.L

Sujet: Name/Gene ID: PCSK2
Subfamily: Serine S8
Family: Protease

Synonyms: PCSK2, Proprotein convertase 2, SPC2, NEC 2, NEC-2, Neuroendocrine convertase 2, PC2, KEX2-like endoprotease 2, NEC2, Prohormone convertase 2

ID gène: 5126

NCBI Accession: NP_002585

UniProt: P16519

Pathways: Peptide Hormone Metabolism, cAMP Metabolic Process, Maintenance of Protein Location, Negative Regulation of Transporter Activity