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PARP1 anticorps (AA 201-300)

PARP1 Reactivité: Humain, Souris, Rat, Poulet WB, ELISA, FACS, IHC (p), IF (p), IF (cc), IHC (fro) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN677903
  • Antigène Voir toutes PARP1 Anticorps
    PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))
    Épitope
    • 20
    • 18
    • 16
    • 15
    • 12
    • 10
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 201-300
    Reactivité
    • 239
    • 67
    • 50
    • 8
    • 7
    • 6
    • 6
    • 5
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Poulet
    Hôte
    • 220
    • 35
    • 1
    • 1
    Lapin
    Clonalité
    • 207
    • 50
    Polyclonal
    Conjugué
    • 150
    • 17
    • 16
    • 16
    • 15
    • 14
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp PARP1 est non-conjugé
    Application
    • 166
    • 129
    • 69
    • 43
    • 34
    • 30
    • 28
    • 27
    • 24
    • 16
    • 15
    • 7
    • 6
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro))
     Réactivité croisée
    Poulet, Humain, Souris, Rat
    Homologie
    Dog,Cow
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human PARP1
    Isotype
    IgG
    Top Product
    Discover our top product PARP1 Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Omar, Aly, Badae: "Vitamin E improves testicular damage in streptozocin-induced diabetic rats, via increasing vascular endothelial growth factor and poly(ADP-ribose) polymerase-1." dans: Andrologia, (2017) (PubMed).

    Yang, Lu, Guo: "Platelet-rich plasma protects rat chondrocytes from interleukin-1β-induced apoptosis." dans: Molecular medicine reports, Vol. 14, Issue 5, pp. 4075-4082, (2016) (PubMed).

    Ma, Liu, Wang, Liu, Chen, Valle, Zuo, Xia, Liu: "Crucial Role of Lateral Size for Graphene Oxide in Activating Macrophages and Stimulating Pro-inflammatory Responses in Cells and Animals." dans: ACS nano, Vol. 9, Issue 10, pp. 10498-515, (2015) (PubMed).

    Zhou, Zhang, Li, Hao, Liu, Wang: "Azithromycin synergistically enhances anti-proliferative activity of vincristine in cervical and gastric cancer cells." dans: Cancers, Vol. 4, Issue 4, pp. 1318-32, (2013) (PubMed).

  • Antigène
    PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))
    Autre désignation
    PARP1 (PARP1 Produits)
    Synonymes
    anticorps ADPRT, anticorps ADPRT 1, anticorps ADPRT1, anticorps ARTD1, anticorps PARP, anticorps PARP-1, anticorps PPOL, anticorps pADPRT-1, anticorps Adprt, anticorps Parp-1, anticorps 5830444G22Rik, anticorps AI893648, anticorps Adprp, anticorps Adprt1, anticorps C80510, anticorps parp-1, anticorps sPARP-1, anticorps BEST:LD21673, anticorps CG17685, anticorps CG17696, anticorps CG17718, anticorps CG40411, anticorps D.PARP, anticorps Dm.pARTa, anticorps Dmel\\CG40411, anticorps LD21673.3prime, anticorps PARP1, anticorps dPARP, anticorps parp, anticorps adprt1, anticorps padprt-1, anticorps ppol, anticorps si:dkey-206f10.3, anticorps wu:fc60f12, anticorps zgc:110092, anticorps poly(ADP-ribose) polymerase 1, anticorps poly (ADP-ribose) polymerase 1, anticorps poly (ADP-ribose) polymerase family, member 1, anticorps Poly-(ADP-ribose) polymerase, anticorps poly(ADP-ribose) polymerase 1 L homeolog, anticorps PARP1, anticorps Parp1, anticorps Parp, anticorps parp1.L, anticorps parp1
    Sujet

    Synonyms: PARP, PPOL, ADPRT, ARTD1, ADPRT1, PARP-1, ADPRT 1, pADPRT-1, Poly [ADP-ribose] polymerase 1, ADP-ribosyltransferase diphtheria toxin-like 1, NAD(+) ADP-ribosyltransferase 1, Poly[ADP-ribose] synthase 1, PARP1

    Background: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.

    ID gène
    142
    UniProt
    P09874
    Pathways
    Apoptose, Caspase Cascade in Apoptosis, Réparation de l'ADN, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location
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