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PKD1 anticorps (AA 131-230)

PKD1 Reactivité: Humain, Souris ELISA, WB, IHC (p), FACS, IF (cc), IF (p), IHC (fro), ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN678083
  • Antigène Voir toutes PKD1 Anticorps
    PKD1 (Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1))
    Épitope
    • 15
    • 8
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 131-230
    Reactivité
    • 38
    • 26
    • 10
    • 1
    • 1
    Humain, Souris
    Hôte
    • 37
    • 1
    Lapin
    Clonalité
    • 38
    Polyclonal
    Conjugué
    • 13
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PKD1 est non-conjugé
    Application
    • 24
    • 16
    • 13
    • 12
    • 12
    • 7
    • 6
    • 3
    • 2
    ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
     Réactivité croisée
    Humain, Souris
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human Polycystin 1
    Isotype
    IgG
  • Indications d'application
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Ren, Xia, Yang, Zhu, Zhang, Chen, Zhao, Sun, Zhao: "Down-regulation of polycystin in lymphatic malformations: possible role in the proliferation of lymphatic endothelial cells." dans: Human pathology, Vol. 65, pp. 231-238, (2017) (PubMed).

    Kito, Saigo, Takeuchi: "Novel Transgenic Mouse Model of Polycystic Kidney Disease." dans: The American journal of pathology, Vol. 187, Issue 9, pp. 1916-1922, (2017) (PubMed).

    Ohata, Herranz-Pérez, Nakatani, Boletta, García-Verdugo, Álvarez-Buylla: "Mechanosensory Genes Pkd1 and Pkd2 Contribute to the Planar Polarization of Brain Ventricular Epithelium." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 31, pp. 11153-68, (2015) (PubMed).

    Chiou, Sang, Cheng, Ho, Wang, Pan: "Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently prevents skin carcinogenesis by suppressing the PKD1-dependent signaling pathway in CD34+ skin stem cells and skin tumors." dans: Carcinogenesis, Vol. 34, Issue 6, pp. 1315-22, (2013) (PubMed).

  • Antigène
    PKD1 (Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1))
    Autre désignation
    Polycystin 1 (PKD1 Produits)
    Synonymes
    anticorps PBP, anticorps Pc-1, anticorps TRPP1, anticorps PC1, anticorps mFLJ00285, anticorps polycystin 1, transient receptor potential channel interacting, anticorps polycystin 1, transient receptor poteintial channel interacting, anticorps polycystin-1, anticorps PKD1, anticorps Pkd1, anticorps LOC749291
    Sujet

    Synonyms: PBP, Pc-1, TRPP1, Polycystin-1, Autosomal dominant polycystic kidney disease 1 protein, PKD1

    Background: Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Acts as a regulator of cilium length, together with PKD2. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity). May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions.

    ID gène
    5310
    UniProt
    P98161
    Pathways
    Myometrial Relaxation and Contraction, Maintenance of Protein Location
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