FOXO3 anticorps (Forkhead Box O3) (pSer253)

Details for Product anti-FOXO3 Antibody No. ABIN684718
Antigène
  • AF6q21
  • FKHRL1
  • FKHRL1P2
  • FOXO2
  • FOXO3A
  • zgc:92176
  • wu:fb50g02
  • wu:fi33f07
  • Fkhrl1
  • Foxo3a
  • FoxO3A
  • 1110048B16Rik
  • 2010203A17Rik
  • C76856
  • Fkhr2
  • FOXO-3
  • FOXO3
  • foxo3a
  • xfoxo3
  • foxO3
  • foxO
  • forkhead box O3
  • forkhead box O3A
  • forkhead box O3 L homeolog
  • FOXO3
  • foxo3a
  • Foxo3
  • foxo3.L
  • foxo3
  • foxO3
Épitope
pSer253
70
46
30
25
17
10
10
10
10
9
9
9
8
8
8
7
7
7
5
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
401
236
204
20
15
11
9
9
8
7
6
5
4
4
3
1
1
1
Hôte
Lapin
329
54
22
1
Clonalité
Polyclonal
Conjugué
Cet anticorp FOXO3 est non-conjugé
21
15
15
15
15
15
15
8
7
5
5
5
2
2
2
2
2
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
270
166
156
79
78
26
19
15
9
9
5
2
1
1
1
Options
Immunogène KLH conjugated synthetic phosphopeptide derived from human FoxO3a around the phosphorylation site of Ser253
Isotype IgG
Specificité This phosphorylation site is homologous to Ser252 in Mouse and Rat.
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others FOXO3 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation Foxo3a (FOXO3 Antibody Extrait)
Sujet

Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.

Subcellular location: Cytoplasm, Nucleus

Synonyms: FOXO2, AF6q21, FKHRL1, FOXO3A, FKHRL1P2, Forkhead box protein O3, AF6q21 protein, Forkhead in rhabdomyosarcoma-like 1, FOXO3

ID gène 2309
UniProt O43524
Pathways Cycle Cellulaire, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis
Indications d'application WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Stock -20 °C
Stockage commentaire Store at -20°C
Date de péremption 12 months
Images (Fournisseur)
Immunohistochemistry (IHC) image for anti-Forkhead Box O3 (FOXO3) (pSer253) antibody (ABIN684718) Formalin-fixed and paraffin embedded human colon carcinoma labeled with Anti-Phospho-...
Western Blotting (WB) image for anti-Forkhead Box O3 (FOXO3) (pSer253) antibody (ABIN684718) Mouse heart lysates probed with Rabbit Anti-FoxO3a Polyclonal Antibody, Unconjugated ...
Produit citée dans: Morales, Abrigo, Acuña, Santos, Bader, Brandan, Simon, Olguin, Cabrera, Cabello-Verrugio: "Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas." dans: Disease models & mechanisms, Vol. 9, Issue 4, pp. 441-9, 2016 (PubMed). Méthode utilisée: Western Blotting (WB) (Échantillon (espèces): Mouse (Murine)).