Insulin Receptor anticorps (Extracellular Domain)

N° du produit ABIN6937574

Cet anticorps Souris Monoclonal détecte spécifiquement Insulin Receptor dans ELISA et Coat. Il présente une réactivité envers Humain.

Aperçu rapide pour Insulin Receptor anticorps (Extracellular Domain) (ABIN6937574)

Antigène: Insulin Receptor (INSR)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Insulin Receptor est non-conjugé

Application: ELISA, Coating (Coat)

Clone: INSR-1661

Détail du produit anti-Insulin Receptor anticorps

Épitope: Extracellular Domain

Specificité: The insulin receptor (INSR) is a heterodimeric protein complex that has an intracellular subunit, which is disulfide-linked to a transmembrane segment. The insulin ligand binds to the INSR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to INSR induces phosphorylation of intra-cellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin. Type 1 diabetes is an autoimmune condition of the endocrine pancreas that results in destruction of insulin secreting cells and a progressive loss in insulin-sensitive glucose uptake by cells.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant fragment of extracellular domain of human Insulin Receptor alpha (exact sequence is proprietary)

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Known_Application: ELISA (Use Ab at 2-4 μg/mL for coating) (Order Ab without BSA)Optimal dilution for a specific application should be determined.

Positive_Control: Jurkat cells. Human pancreas.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur Insulin Receptor

Antigène: Insulin Receptor (INSR)

Autre désignation: INSR

Sujet: CD220, HHF5, HINSR A, INSR, Insulin receptor, Insulin receptor subunit alpha, INSR,Insulin Receptor Alpha
Cellular localisation: Cytoplasm.

Poids moléculaire: 135kDa

ID gène: 3643, 465744

UniProt: P06213

Pathways: Signalisation NF-kappaB, Signalisation RTK, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity