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PPP3R1 anticorps

PPP3R1 Reactivité: Humain IHC (f) Hôte: Souris Monoclonal CALNB-2342 unconjugated
N° du produit ABIN6938230
  • Antigène Voir toutes PPP3R1 Anticorps
    PPP3R1 (Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1))
    Reactivité
    • 28
    • 14
    • 13
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 22
    • 6
    Souris
    Clonalité
    • 22
    • 6
    Monoclonal
    Conjugué
    • 17
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PPP3R1 est non-conjugé
    Application
    • 15
    • 12
    • 7
    • 7
    • 2
    • 2
    • 1
    • 1
    • 1
    Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Specificité
    Calcineurin is an enzyme that dephosphorylates serine and threonine residues in proteins. It is a heterodimer of a 59 kDa catalytic A subunit and a 19 kDa regulatory B subunit that is activated by the binding of calcium ions and calmodulin. Calcineurin is expressed in many tissues, but its levels are highest in the brain, where it may play a role in learning and memory. It has many substrates, including NFAT, a transcription factor that is activated by dephosphorylation. Complexes of the immuno-suppressants cyclosporine and FK506 with immunophilin proteins such as cyclophilin and FKBP12 are potent and specific inhibitors of Calcineurin activity. Alterations in Calcineurin activity are suspected to play a role in cardiac hypertrophy and graft versus host disease in organ transplantation.
    Réactivité croisée (Details)
    Human.
    Purification
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    Immunogène
    Recombinant full-length Calcineurin B protein
    Clone
    CALNB-2342
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product PPP3R1 Anticorps primaire
  • Indications d'application

    Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

    Positive_Control: HeLa, MCF-7 or A431 cells. Prostate, Thyroid or Pancreas.

    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Prepared in 10 mM PBS, WITHOUT BSA and Azide.
    Agent conservateur
    Azide free
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    Date de péremption
    24 months
  • Antigène
    PPP3R1 (Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1))
    Autre désignation
    PPP3R1 (PPP3R1 Produits)
    Synonymes
    anticorps si:ch211-274c22.8, anticorps canb, anticorps CALNB1, anticorps CNB, anticorps CNB1, anticorps CaNB1, anticorps Cnb1, anticorps MCIP1, anticorps protein phosphatase 3, regulatory subunit B, alpha a, anticorps protein phosphatase 3 regulatory subunit B, alpha S homeolog, anticorps protein phosphatase 3 regulatory subunit B, alpha, anticorps protein phosphatase 3, regulatory subunit B, alpha, anticorps protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I), anticorps ppp3r1a, anticorps ppp3r1.S, anticorps PPP3R1, anticorps Ppp3r1
    Sujet
    Calcineurin B, type I (19 kDa), Calcineurin subunit B type 1, CALNB1, CNB1, PPP3R1 protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform, Protein phosphatase 3 regulatory subunit B alpha, Protein phosphatase 3 regulatory subunit B alpha isoform 1,Calcineurin B / PPP3R1
    Cellular localisation: Cytoplasmic and Cell Surface
    Poids moléculaire
    19kDa
    ID gène
    5534, 280604
    UniProt
    P63098
    Pathways
    Signalisation RTK, Signalisation WNT, Fc-epsilon Receptor Signaling Pathway, Protein targeting to Nucleus, VEGF Signaling, BCR Signaling
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