FCGR2A anticorps
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- Antigène Voir toutes FCGR2A Anticorps
- FCGR2A (Fc Fragment of IgG, Low Affinity IIa, Receptor (CD32) (FCGR2A))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp FCGR2A est non-conjugé
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Application
- Immunofluorescence (IF), Flow Cytometry (FACS), Functional Studies (Func)
- Purification
- Purified by Protein A/G
- Immunogène
- Recombinant human FCGR2A protein
- Clone
- FCGR2A-479
- Isotype
- IgG2b kappa
- Top Product
- Discover our top product FCGR2A Anticorps primaire
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- Indications d'application
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Positive Control: K-562 cells. Lymph node, tonsil and placenta.
Known Application: Functional Studies (Order Ab without BSA & Azide), Flow Cytometry (0.5-1 μg/million cells), Immunofluorescence (0.5-1 μg/mL), Optimal dilution for a specific application should be determined.
- Restrictions
- For Research Use only
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- Concentration
- 200 μg/mL
- Buffer
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-80 °C
- Stockage commentaire
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Date de péremption
- 24 months
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- Antigène
- FCGR2A (Fc Fragment of IgG, Low Affinity IIa, Receptor (CD32) (FCGR2A))
- Autre désignation
- FCGR2A (FCGR2A Produits)
- Synonymes
- anticorps CD32, anticorps CD32A, anticorps CDw32, anticorps FCG2, anticorps FCGR2, anticorps FCGR2A1, anticorps FcGR, anticorps IGFR2, anticorps CD32a, anticorps Fc fragment of IgG receptor IIa, anticorps FCGR2A
- Sujet
- This MAb binds most strongly to the IIa isoforms of CD32 (FcRII), a type 1 transmembrane glycoprotein that mediates several functions including phagocytosis, cytotoxicity, and immunomodulation as well as platelet aggregation. Three genes (A, B, and C) encode CD32 and at least 6 isoforms are generated via alternative mRNA splicing, i.e., IIa1, IIa2, IIb1, IIb2, IIb3 and IIc. Monocytes/macrophages, placental trophoblasts and endothelial cells express all isoforms. In addition, the IIb isoform is expressed by B cells, and the IIa isoform by platelets, granulocytes and, weakly, by B cells. NK cells and neutrophils express Isoform IIc. CD32 binds weakly to the Fc region of monomeric IgG but more strongly to IgG aggregates and immune complexes.
- Poids moléculaire
- 40kDa
- ID gène
- 2212
- UniProt
- P12318
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