Insulin Receptor anticorps (Extracellular Domain)

N° du produit ABIN6939799

Cet anticorps anti-Insulin Receptor est un anticorps Souris Monoclonal détectant Insulin Receptor dans ELISA et Coat. Adapté pour Humain.

Aperçu rapide pour Insulin Receptor anticorps (Extracellular Domain) (ABIN6939799)

Antigène: Insulin Receptor (INSR)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Insulin Receptor est non-conjugé

Application: ELISA, Coating (Coat)

Clone: INSR-1661

Détail du produit anti-Insulin Receptor anticorps

Épitope: Extracellular Domain

Purification: Purified by Protein A/G

Immunogène: Recombinant fragment of extracellular domain of human Insulin Receptor alpha (exact sequence is proprietary)

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Positive Control: Jurkat cells. Human pancreas.

Known Application: ELISA (Use Ab at 2-4 μg/mL for coating) (Order Ab without BSA)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur Insulin Receptor

Antigène: Insulin Receptor (INSR)

Autre désignation: INSR

Sujet: The insulin receptor (INSR) is a heterodimeric protein complex that has an intracellular subunit, which is disulfide-linked to a transmembrane segment. The insulin ligand binds to the INSR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to INSR induces phosphorylation of intra-cellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin. Type 1 diabetes is an autoimmune condition of the endocrine pancreas that results in destruction of insulin secreting cells and a progressive loss in insulin-sensitive glucose uptake by cells.

Poids moléculaire: 135kDa

ID gène: 3643

UniProt: P06213

Pathways: Signalisation NF-kappaB, Signalisation RTK, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity