PPP3CA anticorps

N° du produit ABIN6940381

Détail du produit anti-PPP3CA anticorps

Antigène: PPP3CA (Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PPP3CA est non-conjugé

Application: Immunohistochemistry (IHC), Staining Methods (StM)

Purification: Purified by Protein A/G

Immunogène: Recombinant full-length human Calcineurin A protein

Clone: CALNA-2353

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Positive Control: HeLa, MCF-7 or A431 cells. Prostate, Thyroid or Pancreas.

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur PPP3CA

Antigène: PPP3CA (Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA))

Autre désignation: Calcineurin A / PPP3CA (PPP3CA Produits)

Synonymes: anticorps CALN, anticorps CALNA, anticorps CALNA1, anticorps CCN1, anticorps CNA1, anticorps PPP2B, anticorps 2900074D19Rik, anticorps AI841391, anticorps AW413465, anticorps CN, anticorps Caln, anticorps Calna, anticorps CnA, anticorps Calna1, anticorps calcineurin, anticorps caln, anticorps calna, anticorps calna1, anticorps ccn1, anticorps cna1, anticorps ppp2b, anticorps fj46e08, anticorps si:dkeyp-79c2.2, anticorps wu:fj46e08, anticorps ppp3ca, anticorps protein phosphatase 3 catalytic subunit alpha, anticorps protein phosphatase 3, catalytic subunit, alpha isoform, anticorps protein phosphatase 3, catalytic subunit, alpha isozyme, anticorps protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha), anticorps protein phosphatase 3, catalytic subunit, alpha isozyme L homeolog, anticorps serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform, anticorps PPP3CA, anticorps Ppp3ca, anticorps ppp3ca, anticorps ppp3ca.L, anticorps LOC100205420

Sujet: Calcineurin is an enzyme that dephosphorylates serine and threonine residues in proteins. It is a heterodimer of a 59 kDa catalytic A subunit and a 19 kDa regulatory B subunit that is activated by the binding of calcium ions and calmodulin. Calcineurin is expressed in many tissues, but its levels are highest in the brain, where it may play a role in learning and memory. It has many substrates, including NFAT, a transcription factor that is activated by dephosphorylation. Complexes of the immuno-suppressants cyclosporine and FK506 with immunophilin proteins such as cyclophilin and FKBP12 are potent and specific inhibitors of Calcineurin activity. Alterations in Calcineurin activity are suspected to play a role in cardiac hypertrophy and graft versus host disease in organ transplantation.

Poids moléculaire: 62kDa

ID gène: 5530

UniProt: Q08209

Pathways: Signalisation RTK, Signalisation WNT, Fc-epsilon Receptor Signaling Pathway, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Synaptic Membrane, Skeletal Muscle Fiber Development, Protein targeting to Nucleus, VEGF Signaling, BCR Signaling