s100a4 anticorps

N° du produit ABIN6940543

Cet anticorps anti-s100a4 Monoclonal Souris (Clone CPTC-S100A4-3) (ABIN6940543) détecte spécifiquement s100a4 dans WB, IF et FACS. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour s100a4 anticorps (ABIN6940543)

Antigène: s100a4 (S100A4) (S100 Calcium Binding Protein A4 (S100A4))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp s100a4 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: CPTC-S100A4-3

Détail du produit anti-s100a4 anticorps

Fonction: S100A4 / Metastasin / Calvasculin (Marker of Tumor Metastasis) Antibody

Specificité: S100A4 belongs to the S100 super-family of proteins containing 2 EF-hand calcium-binding domains. S100A4 has been implicated in the progression and prognosis of several forms of human cancer, e.g. breast, colorectal, gastric, pancreatic and bladder cancer, SCLC and oesophageal squamous cell carcinoma, among others. Poor prognosis associated with high S100A4 expression is accompanied by clear signs of disease progression, e.g. high histological and clinical grades and involvement of lymph nodes.Also indicative of poor prognosis is high S100A4 expression coupled with reduced E-cadherin expression in pancreatic, oral squamous cell carcinoma and in melanoma. S100A4 expression is inversely related with expression of metastasis suppressor nm23 and with prognosis of breast cancer. S100A4 is overexpressed in highly metastatic cancers, which makes it useful as a marker of tumor progression.

Purification: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant human S100A4 full length protein

Isotype: IgG2c, kappa

Information d'application

Indications d'application:

Positive Control: T98G, HeLa, A549 or A375 cells. Placenta, small intestine.

Known Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Western Blot (1-2 μg/mL), Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur s100a4

Antigène: s100a4 (S100A4) (S100 Calcium Binding Protein A4 (S100A4))

Autre désignation: S100A4

Sujet:

S100 calcium-binding protein A4, Calvasculin, CAPL, Fibroblast specific protein 1 (FSP1), Leukemia multidrug resistance associated protein, Malignant transformation suppression 1 (MTS1), Metastasin, Placental calcium-binding protein

A549 or A375 cells. Placenta, HeLa, small intestine., T98G

Poids moléculaire: 12kDa

ID gène: 6275, 654444

UniProt: P26447

Pathways: S100 Proteins