CDC34 anticorps

N° du produit ABIN6942464

Détail du produit anti-CDC34 anticorps

Antigène: CDC34 (Cell Division Cycle 34 (CDC34))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp CDC34 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc))

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: Full length protein

Clone: 3C2

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur CDC34

Antigène: CDC34 (Cell Division Cycle 34 (CDC34))

Autre désignation: Cdc34 (CDC34 Produits)

Synonymes: anticorps E2-CDC34, anticorps UBC3, anticorps UBCH3, anticorps UBE2R1, anticorps AI327276, anticorps e2-cdc34, anticorps ubc3, anticorps ube2r1, anticorps CDC34, anticorps DNA6, anticorps Ube2r2, anticorps zgc:55452, anticorps fb34h09, anticorps wu:fb34h09, anticorps wu:fe17e09, anticorps zgc:91847, anticorps cell division cycle 34, anticorps cell division cycle 34 L homeolog, anticorps SCF E2 ubiquitin-protein ligase catalytic subunit CDC34, anticorps SCF E2 ubiquitin-protein ligase catalytic subunit, anticorps cell division cycle 34 homolog (S. cerevisiae) a, anticorps cell division cycle 34 homolog (S. cerevisiae) b, anticorps CDC34, anticorps Cdc34, anticorps cdc34.L, anticorps cdc34, anticorps cdc34a, anticorps cdc34b

Sujet:

Synonyms: Ubiquitin-conjugating enzyme E2 R1, (E3-independent) E2 ubiquitin-conjugating enzyme R1, E2 ubiquitin-conjugating enzyme R1, Ubiquitin-conjugating enzyme E2-32 kDa complementing, Ubiquitin-conjugating enzyme E2-CDC34, Ubiquitin-protein ligase R1, CDC34

Background: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:22496338). Cooperates with the E2 UBCH5C and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Performs ubiquitin chain elongation building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. UBE2D3 acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Cooperates with the SCF(SKP2) E3 ligase complex to regulate cell proliferation through ubiquitination and degradation of MYBL2 and KIP1. Involved in ubiquitin conjugation and degradation of CREM isoform ICERIIgamma and ATF15 resulting in abrogation of ICERIIgamma- and ATF5-mediated repression of cAMP-induced transcription during both meiotic and mitotic cell cycles. Involved in the regulation of the cell cycle G2/M phase through its targeting of the WEE1 kinase for ubiquitination and degradation. Also involved in the degradation of beta-catenin. Is target of human herpes virus 1 protein ICP0, leading to ICP0-dependent dynamic interaction with proteasomes (PubMed:10329681, PubMed:10373550, PubMed:10871850, PubMed:11675391, PubMed:12037680, PubMed:15652359, PubMed:17461777, PubMed:17698585, PubMed:19112177, PubMed:19126550, PubMed:19945379, PubMed:20061386, PubMed:20347421).

ID gène: 997

UniProt: P49427