PP2A alpha/beta anticorps
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- Antigène Tous les produits PP2A alpha/beta (PP2A A/B)
- PP2A alpha/beta (PP2A A/B)
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Reactivité
- Humain, Souris, Rat, Poisson zèbre (Danio rerio)
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Hôte
- Lapin
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp PP2A alpha/beta est non-conjugé
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (IHC)
- Réactivité croisée
- Humain, Souris, Rat, Poisson zèbre (Danio rerio)
- Purification
- Purified by Protein A.
- Immunogène
- Human PP2A alpha + beta aa 250-350
- Clone
- 11F10
- Isotype
- IgG
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- Indications d'application
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WB 1:300-5000
IHC-P 1:200-400
IF(ICC) 1:50-200
IHC() - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C for 12 months.
- Date de péremption
- 12 months
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- Antigène
- PP2A alpha/beta (PP2A A/B)
- Autre désignation
- PP2A alpha + beta (PP2A A/B Produits)
- Sujet
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Synonyms: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, Replication protein C, Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform, PP2A-alpha, RP-C, PPP2CA, PP2A-beta, PPP2CB
Background: The catalytic subunit of protein phosphatase 2A (PP2A) is inactivated by in vitro phosphorylation of Tyr-307 by receptor and nonreceptor protein tyrosine kinases. The catalytic subunit of PP2A is phosphorylated by tyrosine-specific protein kinases and associates with a variety of regulatory subunits. Phosphorylation is enhanced in the presence of the phosphatase inhibitor okadaic acid, consistent with an autodephosphorylation reaction. Phosphorylation is catalyzed by p60v-src, p56lck, epidermal growth factor receptors, and insulin receptors. Transient deactivation of PP2A might enhance transmission of cellular signals through kinase cascades within cells. In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases.
- UniProt
- P62714, P67775
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