RANGAP1 anticorps

N° du produit ABIN6944745

Détail du produit anti-RANGAP1 anticorps

Antigène: RANGAP1 (Ran GTPase Activating Protein 1 (RANGAP1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp RANGAP1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: Recombinant protein within human RanGAP1 aa 1-200.

Clone: 2A1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 12 months

Détails sur RANGAP1

Antigène: RANGAP1 (Ran GTPase Activating Protein 1 (RANGAP1))

Autre désignation: RanGAP1 (RANGAP1 Produits)

Synonymes: anticorps Fug1, anticorps RANGAP, anticorps SD, anticorps ATRANGAP1, anticorps RAN GTPASE-ACTIVATING PROTEIN 1, anticorps RAN GTPase activating protein 1, anticorps RanGAP1, anticorps fug1, anticorps rangap1b, anticorps rna1p, anticorps C79654, anticorps mKIAA1835, anticorps rangap1, anticorps rangap1a, anticorps Protein rna1, anticorps CG9999, anticorps CT28175, anticorps Dmel\CG9999, anticorps RGP1_DROME, anticorps Ran, anticorps RanGAP, anticorps RanGap, anticorps RanGap1, anticorps Scl, anticorps Sd, anticorps Sd-RanGAP, anticorps Sd-RanGap, anticorps dRanGAP, anticorps ranGAP, anticorps ranGap, anticorps rangap, anticorps zgc:154097, anticorps Ran GTPase activating protein 1, anticorps RAN GTPase activating protein 1, anticorps ran GTPase activating protein 1, anticorps Ran GTPase activating protein 1 S homeolog, anticorps Ran GTPase activating protein 1 L homeolog, anticorps Ran GAP Rna1, anticorps Ran GTPase activating protein, anticorps RAN GTPase activating protein 1a, anticorps RANGAP1, anticorps TERG_02084, anticorps rangap1.S, anticorps Rangap1, anticorps rangap1.L, anticorps rna1, anticorps RanGAP, anticorps rangap1a

Sujet:

Synonyms: Ran GTPase-activating protein 1, RanGAP1, RANGAP1, KIAA1835

Background: The small Ras related protein Ran, also called TC4, is a nuclear localized GTPase implicated in a diverse array of cellular processes including DNA replication, entry into and exit from mitosis and the transport of RNA and proteins through the nuclear pore complex. Like Ras, active Ran GTP and inactive Ran GDP levels are tightly regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). The abundant GEF RCC1 (regulator of chromosome condensation 1) increases the rate at which Ran exchanges GDP for GTP. Ran GAP1 opposes the effects of RCC1 by increasing the rate at which Ran hydrolyzes GTP to GDP. A protein designated Ran BP1 has no intrinsic GAP activity and functions as a GEF inhibitor deactivating RCC1 and thereby indirectly increasing the ratio of Ran GDP to Ran GTP. Ran BP2 has been proposed as the Ran GTP docking site at the periphery of the nuclear pore complex.

ID gène: 5905

UniProt: P46060

Pathways: M Phase, Protein targeting to Nucleus