Caspase 12 anticorps (AA 21-100) (Biotin)

N° du produit ABIN6982943

L’anticorps Lapin Polyclonal anti-Caspase 12 a été validé pour WB, ELISA, IHC (p) et IHC (fro). Il convient pour détecter Caspase 12 dans des échantillons de Souris.

Aperçu rapide pour Caspase 12 anticorps (AA 21-100) (Biotin) (ABIN6982943)

Antigène: Caspase 12 (CASP12) (Caspase 12 (Gene/pseudogene) (CASP12))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Caspase 12 est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-Caspase 12 anticorps (Biotin)

Épitope: AA 21-100

Réactivité croisée: Souris

Homologie: Human

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Caspase-12

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur Caspase 12

Antigène: Caspase 12 (CASP12) (Caspase 12 (Gene/pseudogene) (CASP12))

Autre désignation: Caspase-12

Sujet:

Synonyms: Caspase-12, UNQ9415, Apoptosis related cysteine protease, CASP 12, casp12, CASP12P1, Caspase 12 pseudogene 1, CASP-12, casp12, caspase 12 (gene/pseudogene), Caspase12, CASPC_HUMAN, OTTHUMP00000207026, OTTHUMP00000207028, OTTHUMP00000207031, OTTHUMP00000207032, OTTHUMP00000219058, UNQ9415.

Background: Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011]

ID gène: 100506742

UniProt: Q6UXS9

Pathways: Apoptose, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response